1215212-35-3

Upstream product

• 188290-36-0 thiophene 
• 156545-07-2 3,5-difluorophenylboronic acid 
• 1003-09-4 2-bromothiophene 
• 17984-89-3 triethoxy(thiophen-2-yl)silane 
• 2265-91-0 1,3-difluoro-5-iodobenzene 

Downstream Products

• 1365721-30-7 2-({[5-(3,5-difluorophenyl)thiophen-2-yl]sulfonyl}amino)-5-methyl-1,3-thiazole-4-carboxylic acid 
• 1365721-98-7 5-(3,5-difluorophenyl)thiophene-2-sulfonyl chloride 

Relevant academic research and scientific papers

Manganese(III) acetate-mediated synthesis of biaryls under microwave irradiation

Manganese(III) acetate (Mn(OAc)3)-mediated synthesis of biaryls and heterobiaryls starting from arylboronic acid was developed under microwave irradiation in high yields. Microwaves were also used for the synthesis of Mn(OAc)3 from KMnO4 and acetic acid. Additional irradiation of this in situ generated Mn(OAc)3 with arylboronic acids, which in turn furnished the biaryls in high yields in a one pot reaction. This is superior from the point of view of yield, short reaction time, sensitive functional group toleration, and more environmentally friendly than the reported methods with a minimum amount of benzene and thiophene as a reagent but not as a solvent.

Copper-catalyzed Hiyama coupling of (hetero)aryltriethoxysilanes with (hetero)aryl iodides

A CuI-catalyzed Hiyama coupling was achieved, which proceeds in the absence of an ancillary ligand for aryl-heteroaryl and heteroaryl-heteroaryl couplings. A P,N-ligand is required to obtain the best product yields for aryl-aryl couplings. In addition to facilitating transmetalation, CsF is also found to function as a stabilizer of the [CuAr] species, potentially generated as an intermediate after transmetalation of aryltriethoxysilanes with Cu I-catalysts in the absence of ancillary ligands.

NEW COMPOUNDS

A compound of formula (I), wherein A is S, O or a double bond, and L is a substituted thiazolyl, phenyl or pyridyl. The compound is useful for the treatment of inflammation and cancer.