121554-16-3Relevant academic research and scientific papers
Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors
Li, Jing,Wu, Fangping,Liu, Xingguo,Zou, Yake,Chen, Huixiong,Li, Zheng,Zhang, Lei
, p. 20 - 30 (2017)
A diverse library of 1-phenyl-pyrazole-4-carboxylic acid derivatives were synthesized and evaluated for their inhibitory potency against xanthine oxidoreductase (XOR) in vitro and vivo, and the structure-activity relationship (SAR) analyses were also pres
AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES
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Page/Page column 38, (2008/12/08)
A novel amine compound represented by the following formula (I), which is superior in immunosuppressive action, rejection suppressive action and the like, and shows reduced side effects such as bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or hydrates thereof, or solvate, as well as a pharmaceutical composition containing this compound and a pharmaceutically acceptable carrier. wherein R is a hydrogen atom or P(=O)(OH)2, X is an oxygen atom or a sulfur atom, Y is CH2CH2 or CH=CH, R1 is cyano or alkyl having a carbon number of 1 to 4 and substituted by a halogen atom(s), R2 is alkyl having a carbon number of 1 to 4 and optionally substituted by a hydroxyl group(s) or a halogen atom(s), R3 and R4 may be the same or different and each is a hydrogen atom or alkyl having a carbon number of 1 to 4, and n is 5 - 8.
The Synthesis and Transition Temperatures of Some Lateral Cyano-Substituted-1,1':4',1''-terphenyls
Hird, Michael,Gray, George W.,Toyne, Kenneth J.
, p. 205 - 221 (2007/10/02)
In recent years we have used palladium-catalysed cross-coupling procedures to prepare a large number of very interesting lateral mono- and di-fluoro-substituted terphenyls.Similar methodology has been applied in the synthesis of lateral cyano-substituted terphenyls to assess the extent to which the mesophases of such systems can tolerate the larger cyano group; the synthetic routes to these compounds are discussed in detail.The compounds with the lateral cyano-substituent in the centre ring have very low melting points and liquid crystal phases exhibited (SC, SA and nematic) are dependent on the terminal substituents.The compounds with the cyano-substituent at the edge of the terphenyl core are still quite low melting and they have very wide SA ranges. Keywords: lateral cyano-substitution, 1,1':4',1''-terphenyls, palladium-catalysed cross-coupling
