121554-16-3Relevant articles and documents
Synthesis and bioevaluation of 1-phenyl-pyrazole-4-carboxylic acid derivatives as potent xanthine oxidoreductase inhibitors
Li, Jing,Wu, Fangping,Liu, Xingguo,Zou, Yake,Chen, Huixiong,Li, Zheng,Zhang, Lei
, p. 20 - 30 (2017)
A diverse library of 1-phenyl-pyrazole-4-carboxylic acid derivatives were synthesized and evaluated for their inhibitory potency against xanthine oxidoreductase (XOR) in vitro and vivo, and the structure-activity relationship (SAR) analyses were also pres
The Synthesis and Transition Temperatures of Some Lateral Cyano-Substituted-1,1':4',1''-terphenyls
Hird, Michael,Gray, George W.,Toyne, Kenneth J.
, p. 205 - 221 (2007/10/02)
In recent years we have used palladium-catalysed cross-coupling procedures to prepare a large number of very interesting lateral mono- and di-fluoro-substituted terphenyls.Similar methodology has been applied in the synthesis of lateral cyano-substituted terphenyls to assess the extent to which the mesophases of such systems can tolerate the larger cyano group; the synthetic routes to these compounds are discussed in detail.The compounds with the lateral cyano-substituent in the centre ring have very low melting points and liquid crystal phases exhibited (SC, SA and nematic) are dependent on the terminal substituents.The compounds with the cyano-substituent at the edge of the terphenyl core are still quite low melting and they have very wide SA ranges. Keywords: lateral cyano-substitution, 1,1':4',1''-terphenyls, palladium-catalysed cross-coupling
