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121569-61-7

ANTIBIOTIC UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01, first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. It is an indolocarbazole with comparable activity to its isomer UCN-01 and is known for its cytotoxic properties.
Used in Pharmaceutical Industry:
ANTIBIOTIC UCN-02 is used as a protein kinase inhibitor for its ability to inhibit protein kinase C with slightly reduced potency compared to UCN-01. This property makes it a potential candidate for the development of drugs targeting various diseases, including cancer.
Used in Cancer Research:
ANTIBIOTIC UCN-02 is used as a cytotoxic agent for its ability to inhibit the growth of HeLa S3 cells, a type of cervical cancer cell line. This characteristic makes it a valuable tool in cancer research for understanding the mechanisms of cell growth inhibition and potential therapeutic applications.
Used in Drug Development:
ANTIBIOTIC UCN-02 is used as a lead compound in drug development due to its potential as a protein kinase inhibitor and cytotoxic agent. Its properties can be further explored and optimized to create more effective and selective drugs for various therapeutic applications.

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  • 121569-61-7 Structure

  • Basic information

    1. Product Name: ANTIBIOTIC UCN-02
    2. Synonyms: ANTIBIOTIC UCN-02;UCN-02
    3. CAS NO:121569-61-7
    4. Molecular Formula: C28H26N4O4
    5. Molecular Weight: 482.537
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 121569-61-7.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 705.7°C at 760 mmHg
    3. Flash Point: 380.6°C
    4. Appearance: /
    5. Density: 1.63g/cm3
    6. Vapor Pressure: 6.64E-21mmHg at 25°C
    7. Refractive Index: 1.827
    8. Storage Temp.: N/A
    9. Solubility: Soluble in DMSO
    10. PKA: 12.25±0.70(Predicted)
    11. CAS DataBase Reference: ANTIBIOTIC UCN-02(CAS DataBase Reference)
    12. NIST Chemistry Reference: ANTIBIOTIC UCN-02(121569-61-7)
    13. EPA Substance Registry System: ANTIBIOTIC UCN-02(121569-61-7)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 121569-61-7(Hazardous Substances Data)

121569-61-7 Usage

references

[1] takahashi, i. ,saitoh, y.,yoshida, m., et al. ucn-01 and ucn-02, new selective inhibitors of protein kinase c. ii. purification, physico-chemical properties, structural determination and biological activities. j.antibiot.(tokyo) 42(4), 571-576 (1989).[2] newton a c. protein kinase c: structure, function, and regulation[j]. journal of biological chemistry, 1995, 270(48): 28495-28498.

Check Digit Verification of cas no

The CAS Registry Mumber 121569-61-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,5,6 and 9 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 121569-61:
(8*1)+(7*2)+(6*1)+(5*5)+(4*6)+(3*9)+(2*6)+(1*1)=117
117 % 10 = 7
So 121569-61-7 is a valid CAS Registry Number.
InChI:InChI=1/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27+,28+/m1/s1

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