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121572-37-0

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121572-37-0 Usage

Chemical Properties

White solid

Check Digit Verification of cas no

The CAS Registry Mumber 121572-37-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,5,7 and 2 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 121572-37:
(8*1)+(7*2)+(6*1)+(5*5)+(4*7)+(3*2)+(2*3)+(1*7)=100
100 % 10 = 0
So 121572-37-0 is a valid CAS Registry Number.

121572-37-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl N-[4-chloro-6-(methoxycarbonylamino)pyridin-2-yl]carbamate

1.2 Other means of identification

Product number -
Other names METHYL 6-METHOXYFORMAMIDO-4-CHLOROPYRIDIN-2-YLCARBAMATE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:121572-37-0 SDS

121572-37-0Relevant articles and documents

New anticancer agents: Alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)carbamates

Temple Jr.,Rener,Comber

, p. 2363 - 2367 (2007/10/02)

The ethyl (1,2-dihydropyrido[3,4-b]pyrazin-7-yl)carbamates have been reported to bind with cellular tubulin, to produce an accumulation of cells at mitosis, and to exhibit cytotoxic activity against experimental neoplasms in mice. Studies on the disposition of ethyl (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl)carbamate (8) in mice showed that one metabolite was formed by cleavage of the ethyl carbamate moiety. Analogues with alterations in the carbamate group were prepared by transformations at the carbamate of 8, by reductive cyclization of nitropyridine intermediates, and by hybride reduction of the ring of heteroaromatic compounds. In vitro and in vivo evaluations of analogues indicated that a carbamate group was required for activity. No significant change in activity was observed when ethyl was replaced by methyl. However, activity was reduced when ethyl was replaced with bulky aliphatic groups and when ethoxy was replaced with a methylamino group. Also, the activity of 8 was decreased by acetylation of the 5-amino group and was destroyed by substitution of an amino group at the 8-position.

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