1215969-79-1

Basic information

• Product Name: 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one
• Synonyms: 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one
• CAS NO: 1215969-79-1
• Molecular Weight: 204.604
• Mol File: 1215969-79-1.mol

Chemical Properties

• CAS DataBase Reference: 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one(1215969-79-1)
• EPA Substance Registry System: 3-chloro-1-(3',4'-difluorophenyl)-propan-1-one(1215969-79-1)

Safety Data

• Hazardous Substances Data: 1215969-79-1(Hazardous Substances Data)

Upstream product

• 367-11-3 ortho-difluorobenzene 
• 625-36-5 2-chloropropionyl chloride 

Downstream Products

• 1247088-58-9 C₁₉H₁₈F₂N₂O 
• 1160186-34-4 tert-butyl (3S,4R)-3-{[[2-chloro-5-(2-methoxyethyl)benzyl](cyclopropyl)amino]carbonyl}-4-(3,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate 
• 1247088-59-0 C₁₇H₂₁F₂NO₅ 
• 1247091-41-3 C₁₉H₁₉F₂NO₃ 

Relevant articles and documents

NOVEL PROCESS FOR PREPARING PHENYLCYCLOPROPYLAMINE DERIVATIVES USING NOVEL INTERMEDIATES

Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.

Synthesis of nitrogen substituted cyclopropanes

The invention is about a new synthetic pathway for the preparation of enantiomerically pure nitrogen substituted cyclopropanes, in particular the trans-cyclopropanamine (1), a key intermediate in the synthesis of Ticagrelor: The invention also relates to

SYNTHESIS OF 2-(3,4-DIFLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID

The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

Synthesis of 2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.

NOVEL PROCESSES FOR PREPARING TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF

Provided herein is a novel process for the preparation of triazolo[4,5-d]pyrimidine derivatives. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of highly pure ticagrelor or a pharmaceutically acceptable salt thereof. Provided further herein is a novel process for the preparation of substituted cyclopentanamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a ticagrelor intermediate, 2-[[(3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d] [1,3]- dioxol-4-yl]oxy]- 1 -ethanol.

Renin inhibitors for the treatment of hypertension: Design and optimization of a novel series of tertiary alcohol-bearing piperidines

The design and optimization of a novel series of renin inhibitor is described herein. Strategically, by committing the necessary resources to the development of synthetic sequences and scaffolds that were most amenable for late stage structural diversification, even as the focus of the SAR campaign moved from one end of the molecule to another, highly potent renin inhibitors could be rapidly identified and profiled.

NOVEL PROCESS FOR PREPARING PHENYLCYCLOPROPYLAMINE DERIVATIVES USING NOVEL INTERMEDIATES

Provided herein is a novel process for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein is a novel, commercially viable and industrially advantageous process for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. The intermediate is useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.