121617-75-2Relevant academic research and scientific papers
Synthesis of Trifluoromethyl-Substituted Pyrethroids
Naegele, Ulli M.,,Hanack, Michael
, p. 847 - 852 (2007/10/02)
1,1,1-Trifluoroacetone (2) reacts with the phosphorus ylids 1 to give predominantely the (E)-trifluoromethyl-substituted olefins 3a - d.Reaction of 3-trifluoromethyl-2-butenenitrile (3a) with (ethoxycarbonylmethylene)dimethylsulfurane (4a) affords a mixture of four diastereomers of ethyl 3-cyano-2-methyl-2-(trifluoromethyl)cyclopropanecarboxylate (5a).Compound 5a can be reduced by tri-n-hexylsilane to give ethyl 3-formyl-2-methyl-2-(trifluoromethyl)cyclopropanecarboxylate (trifluorocaronaldehydic acid ethyl ester) (6).Monotrifluoromethyl-substituted pyrethroid esters7a, 7b, and 7c were obtained from the aldehyde 6.Compound 7a is converted into the pyrethroid 7f.
