121668-47-1

Basic information

• Product Name: (Z)-2,3-dihydro-3-(2-hydroxy-phenylmethylene)-(1H)-isoindolinone
• CAS NO: 121668-47-1
• Molecular Weight: 237.258
• Mol File: 121668-47-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (Z)-2,3-dihydro-3-(2-hydroxy-phenylmethylene)-(1H)-isoindolinone(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2,3-dihydro-3-(2-hydroxy-phenylmethylene)-(1H)-isoindolinone(121668-47-1)
• EPA Substance Registry System: (Z)-2,3-dihydro-3-(2-hydroxy-phenylmethylene)-(1H)-isoindolinone(121668-47-1)

Safety Data

• Hazardous Substances Data: 121668-47-1(Hazardous Substances Data)

Upstream product

• 14352-51-3 3-iminoisoindolinone 
• 90-02-8 salicylaldehyde 
• 121668-44-8 2-(2-benzofuranyl)-benzonitrile 

Downstream Products

• 129075-30-5 2,3-dihydro-2-methyl-3-(2-methoxyphenylmethylene)-1H-isoindol-1-one 
• 129053-50-5 (Z)-2,3-dihydro-3-(2-methoxyphenylmethylene)-1H-isoindol-1-one 

Relevant articles and documents

A New Alkaline Rearrangement of the Benzofuran Skeleton. One Step Transformation of 2-(2-Benzofuranyl)benzonitriles Into (Z)-Phenylmethyleneisoindolinones

The alkaline hydrolysis of 2-(2-benzofuranyl)benzonitriles 2 by potassium hydroxide under reflux in ethanol stops at the corresponding amides 5.Using other solvents (ethylene glycol or methoxyethanol) at higher temperatures, one can obtain either the amides 5, the acids 1 or rearrangement products depending on the experimental conditions.The rearrangement products were identified as (Z)-phenylmethylenedihydroisoindolinones 6 resulting from opening of the furan ring.The structures of the compounds 6 were established by 1H nmr spectroscopy (nOe) and X-ray crystallography.