129053-50-5

Upstream product

• 14352-51-3 3-iminoisoindolinone 
• 135-02-4 ortho-anisaldehyde 
• 121668-47-1 (Z)-2,3-dihydro-3-(2-hydroxy-phenylmethylene)-(1H)-isoindolinone 
• 74-88-4 methyl iodide 
• 891194-28-8 methyl 1-oxo-1,3-dihydro-2H-isoindole-2-carboxylate 
• 529-28-2 4-iodoanisol 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 167558-57-8 1,1-Dibromo-2-(o-carboxamidophenyl)ethene 
• 136918-14-4 phthalimide 
• 40888-26-4 2-ethynylbenzonitrile 
• 5159-41-1 2-iodobenzyl alcohol 
• 891194-31-3 C₁₁H₁₂INO₄ 
• 129053-52-7 (E)-2,3-dihydro-3-(2-methoxyphenylmethylene)-1H-isoindol-1-one 

Relevant academic research and scientific papers

Reductive coupling of phthalimides with ketones and aldehydes by low-valent titanium: One-pot synthesis of alkylideneisoindolin-1-ones

The reductive coupling of phthalimides with ketones and aldehydes by Zn-TiCl4 in THF gave two- and four-electron reduced products, 3-hydroxy-3-(1-hydroxyalkyl)isoindolin-1-ones and alkylideneisoindolin-1-ones, selectively by controlling the rea

A tandem elimination-cyclization-suzuki approach: Efficient one-pot synthesis of functionalized (Z)-3-(arylmethylene)isoindolin-1-ones

(Chemical Equation Presented) A novel and efficient one-pot regioselective elimination-cyclization-Suzuki approach was developed to afford (Z)-3-arylmethyleneisoindolin-1-ones in good to excellent yields from easily accessible o-gem-dihalovinylbenzamides and organoboron reagents.

A stereoselective synthesis of (Z)-3-aryl and alkylmethylidene-1H- isoindolin-1-ones

A series of Z-configured (hetero)aryl and alkylmethylideneisoindolin-1-ones has been efficiently prepared by treatment of N-methoxycarbonylisoindolin-1- ones with a base and reaction with selected aldehydes. The parent N-acylated isoindolin-1-ones have be

Solvent effects on aza-anionic cycloaromatization of 2-(2-substituted-ethynyl)benzonitriles

The methanolysis of 2-(2-aryl ethynyl)benzonitriles is accelerated when the polar aprotic solvents are added, which could enhance the 6-endo pathway and give isoquinolones, though the 5-exo pathway is occupied mostly. The yields of products would also be

A New Alkaline Rearrangement of the Benzofuran Skeleton. One Step Transformation of 2-(2-Benzofuranyl)benzonitriles Into (Z)-Phenylmethyleneisoindolinones

The alkaline hydrolysis of 2-(2-benzofuranyl)benzonitriles 2 by potassium hydroxide under reflux in ethanol stops at the corresponding amides 5.Using other solvents (ethylene glycol or methoxyethanol) at higher temperatures, one can obtain either the amides 5, the acids 1 or rearrangement products depending on the experimental conditions.The rearrangement products were identified as (Z)-phenylmethylenedihydroisoindolinones 6 resulting from opening of the furan ring.The structures of the compounds 6 were established by 1H nmr spectroscopy (nOe) and X-ray crystallography.