121670-33-5

Basic information

• Product Name: 3-(4-METHOXYPHENYL)PROPANOHYDRAZIDE
• Synonyms: 3-(4-METHOXYPHENYL)PROPANOHYDRAZIDE;3-(4-methoxyphenyl)propanohydrazide(SALTDATA: FREE);3-(4-methoxyphenyl)propionohydrazide;Oprea1_484443
• CAS NO: 121670-33-5
• Molecular Formula: C₁₀H₁₄N₂O₂
• Molecular Weight: 194.24
• Mol File: 121670-33-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 412.2°C at 760 mmHg
• Flash Point: 203.1°C
• Appearance: /
• Density: 1.126g/cm³
• Vapor Pressure: 5.29E-07mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: 3-(4-METHOXYPHENYL)PROPANOHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHOXYPHENYL)PROPANOHYDRAZIDE(121670-33-5)
• EPA Substance Registry System: 3-(4-METHOXYPHENYL)PROPANOHYDRAZIDE(121670-33-5)

Safety Data

• Hazardous Substances Data: 121670-33-5(Hazardous Substances Data)

Usage

General Description

3-(4-Methoxyphenyl)propanohydrazide is a chemical compound with the formula C10H14N2O2. It is a hydrazide derivative, meaning that it contains a hydrazine functional group (N-NH2) attached to a carbonyl group. 3-(4-METHOXYPHENYL)PROPANOHYDRAZIDE is commonly used in the pharmaceutical industry as a building block in the synthesis of various drugs and pharmaceutical compounds. Additionally, it has been investigated for its potential biological activities, such as its anti-inflammatory and anti-cancer properties. Its ability to inhibit the growth of cancer cells and its potential for targeting specific enzymes in the body make it a promising compound for further research and development in the field of medicinal chemistry.

InChI:InChI=1/C10H14N2O2/c1-14-9-5-2-8(3-6-9)4-7-10(13)12-11/h2-3,5-6H,4,7,11H2,1H3,(H,12,13)

Upstream product

• 15893-42-2 3-(4-methoxyphenyl)propionyl chloride 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 15823-04-8 methyl 3-(4-methoxyphenyl)propionate 

Downstream Products

• 156141-38-7 methyl 2-[3-(4-methoxyphenyl)propanoyl]hydrazinecarboxylate 
• 623176-91-0 N'-[3-(4-methoxyphenyl)propionyl]hydrazinecarboxylic acid n-propyl amide 
• 1380492-45-4 4-mesityl-3-[2-(4-methoxyphenyl)ethyl]-4H-1,2,4-triazole 
• 1380492-46-5 3-[2-(4-methoxyphenyl)ethyl]-4-phenyl-4H-1,2,4-triazole 
• 1380492-47-6 4-(2 6-diisopropylphenyl)-3-[2-(4-methoxyphenyl)ethyl]-4H-1,2,4-triazole 
• 1380492-55-6 4-cyclohexyl-3-[2-(4-methoxyphenyl)ethyl]-4H-1,2,4-triazole 
• 1380492-42-1 2-[2-(4-methoxyphenyl)ethyl]-1,3,4-oxadiazole 
• 894317-19-2 N-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propanoyl)hydrazinecarboxamide 
• 1218819-84-1 3-(4-methoxyphenethyl)-4-(3-methoxyphenyl)-1H-1,2,4-triazol-5(4H)-one 
• 890944-59-9 N-(3-methoxyphenyl)-2-(3-(4-methoxyphenyl)propanoyl)hydrazinecarboxamide 
• 1353757-13-7 3-(4-methoxyphenethyl)-4-(2-methoxyphenyl)-1H-1,2,4-triazol-5(4H)-one 
• 893130-51-3 N-(2-methoxyphenyl)-2-(3-(4-methoxyphenyl)propanoyl)hydrazinecarboxamide 
• 1394137-55-3 C₁₈H₁₄F₂N₄OS 
• 1370002-62-2 C₁₈H₁₅ClN₄OS 

Relevant articles and documents

Similarities and differences in the crystal packing of methoxybenzyl and methoxyphenylethyl-1,3,4-oxadiazole-2(3H)-thiones

This work reports the crystal and molecular structures of five 1,3,4-oxadiazol-2(3H)-thiones derived from 2, 3 and 4-methoxy substituted 2-phenylacetic acid and 2- and 4-methoxy substituted 3-phenylpropanoic acid. The methoxybenzyl-1,3,4-oxadiazol-2(3H)-thiones are V-shaped while the corresponding methoxyphenylethyl-systems are close to planar, which impacts the solid state molecular packing arrangement. For molecules 1-4, inversion related N-H...S hydrogen bonds generating R22(8) rings dominate the packing, supported by an eclectic mix of C-H...O, C-H...S, C-H...π and π...π contacts that stack the molecules into interconnected columns. In contrast, each of the two unique molecules in the asymmetric unit of 5 forms N-H...O contacts with like molecules augmented by C-H...S contacts for one molecule and C-H...O contacts for the other to generate planar layers that are interconnected though a series of π...π stacking interactions. The Royal Society of Chemistry.

Synthesis, urease inhibition, antioxidant and antibacterial studies of some 4-Amino-5-aryl-3H-1,2,4-triazole-3-thiones and their 3,6-Disubstituted 1,2,4-Triazolo[3,4-b]1,3,4-thiadiazole derivatives

A new series of 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones, bearing various methoxybenzyl- and methoxyphenethyl groups, was synthesized by refluxing potassium hydrazinecarbodithioate salts in dilute aqueous solution of hydrazine hydrate. These salts were formed by the reaction of acid hydrazides and carbon disulfide in methanolic potassium hydroxide solution at 0-5 °C. 4-Amino-5-aryl-3H-1,2,4-triazole-3-thiones were condensed with different substituted aromatic acids to yield 3,6-disubstituted-1,2,4-triazolo[3,4-b]1,3, 4-thiadiazoles. The structures of the synthesized compounds were characterized by infrared (IR), 1H and 13C nuclear magnetic resonance (NMR), elemental analysis and mass spectrometric (MS) studies. All the synthesized compounds were screened for their urease inhibition, antioxidant and antibacterial activities. Some compounds showed excellent urease inhibition activity, more than the standard drug. Others exhibited potent antioxidant activity. All the compounds showed significant antibacterial activities as compared to the standard drug.

Tunable protic ionic liquids as solvent-catalysts for improved synthesis of multiply substituted 1,2,4-triazoles from oxadiazoles and organoamines

More than green alternatives to traditional volatile molecular organic solvents, protic ionic liquids as dual solvent-catalysts have been successfully used to promote reactions of organoamines with oxadiazoles to afford sterically hindered 1,2,4-triazoles. Among the tested protic ionic liquids, pyridinium trifluoroacetate and acetate showed the highest efficiency for the reactions of arylamines and alkylamines, respectively, indicating that tunable catalysis could be readily effected with protic ionic liquid solvent-catalysts by simply tuning their cation and anion counterparts. A general and efficient approach has been developed for synthesis of multiply substituted 1,2,4-triazoles based on the tunable protic ionic liquid solvent-catalyst systems.