1216785-58-8Relevant articles and documents
l-Threonine-catalysed asymmetric α-hydroxymethylation of cyclohexanone: application to the synthesis of pharmaceutical compounds and natural products
Chen, Anqi,Xu, Jin,Chiang, Winnie,Chai, Christina L.L.
experimental part, p. 1489 - 1495 (2010/04/04)
l-Threonine has been found to be an efficient catalyst for the asymmetric α-hydroxymethylation of cyclohexanone with formalin. Reducing the amount of water in the reaction by the addition of magnesium sulfate as a dehydrating additive significantly improves the yield. Applications of (S)-2-hydroxymethyl cyclohexanone and the chiral building blocks derived therefrom for the synthesis of pharmaceutical compounds and natural products have been explored.