754991-19-0Relevant academic research and scientific papers
Direct asymmetric α-hydroxymethylation of ketones in homogeneous aqueous solvents
Pasternak, Monika,Paradowska, Joanna,Rogozińska, Maria,Mlynarski, Jacek
, p. 4088 - 4090 (2010)
A chiral prolinamide-based zinc complex promotes the aldol reaction of ketones with aqueous formaldehyde, giving the corresponding adducts in good yields and high ees. The efficient direct aldol reaction of formaldehyde with ketones in homogeneous aqueous
l-Threonine-catalysed asymmetric α-hydroxymethylation of cyclohexanone: application to the synthesis of pharmaceutical compounds and natural products
Chen, Anqi,Xu, Jin,Chiang, Winnie,Chai, Christina L.L.
experimental part, p. 1489 - 1495 (2010/04/04)
l-Threonine has been found to be an efficient catalyst for the asymmetric α-hydroxymethylation of cyclohexanone with formalin. Reducing the amount of water in the reaction by the addition of magnesium sulfate as a dehydrating additive significantly improves the yield. Applications of (S)-2-hydroxymethyl cyclohexanone and the chiral building blocks derived therefrom for the synthesis of pharmaceutical compounds and natural products have been explored.
