1217088-67-9

Basic information

• Product Name: 3-[3-(MethylaMino)phenyl]-3-oxopropanenitrile
• Synonyms: 3-[3-(MethylaMino)phenyl]-3-oxopropanenitrile
• CAS NO: 1217088-67-9
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• Mol File: 1217088-67-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[3-(MethylaMino)phenyl]-3-oxopropanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[3-(MethylaMino)phenyl]-3-oxopropanenitrile(1217088-67-9)
• EPA Substance Registry System: 3-[3-(MethylaMino)phenyl]-3-oxopropanenitrile(1217088-67-9)

Safety Data

• Hazardous Substances Data: 1217088-67-9(Hazardous Substances Data)

Upstream product

• 192632-34-1 ethyl 3-(methylamino)benzoate 
• 75-05-8 acetonitrile 

Downstream Products

• 1217089-43-4 C₁₀H₁₂N₄ 

Relevant articles and documents

Design, synthesis, and evaluation of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors

Described herein is design, synthesis, and biological evaluation of novel series of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines acting as inhibitors of type 4 phosphodiesterase (PDE4) which is known as a good target for the treatment of asthma and COPD. For this purpose, structure optimization was conducted with the aid of structure-based drug design using the known X-ray crystallography. Also, biological effects of these compounds on the target enzyme were evaluated by using in vitro assays, leading to the potent and selective PDE-4 inhibitor (IC50 10 nM).