1217193-98-0

Basic information

• Product Name: 5-(3,4-dimethoxybenzyl)-3-(2,4-dimethoxyphenyl)-4,5-dihydroisoxazole
• CAS NO: 1217193-98-0
• Molecular Weight: 357.406
• Mol File: 1217193-98-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(3,4-dimethoxybenzyl)-3-(2,4-dimethoxyphenyl)-4,5-dihydroisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3,4-dimethoxybenzyl)-3-(2,4-dimethoxyphenyl)-4,5-dihydroisoxazole(1217193-98-0)
• EPA Substance Registry System: 5-(3,4-dimethoxybenzyl)-3-(2,4-dimethoxyphenyl)-4,5-dihydroisoxazole(1217193-98-0)

Safety Data

• Hazardous Substances Data: 1217193-98-0(Hazardous Substances Data)

Upstream product

• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 31874-34-7 2,4-dimethoxybenzaldoxime 
• 97-53-0 4-allylguaiacol 

Relevant articles and documents

Synthesis of novel isoxazolines via 1,3-dipolar cycloaddition and evaluation of anti-stress activity

We have synthesized a series of novel isoxazolines via 1,3-dipolar cycloaddition of in situ generated nitrile oxide from 2,4-dimethoxy benzaldoxime and naphthaldehyde oxime with 4-allyl-2-methoxyphenol derivatives. The synthesized compounds were evaluated for anti-stress activity in acute stress (AS) induced peripheral changes. Adult male Sprague-Dawley rats, subjected to AS, cause a significant increase in gastric ulceration, adrenal gland weight, plasma glucose, corticosterone levels, and creatine kinase activity. Compounds 3d, 3g, 5b, 5c, 5d, and 5g displayed most promising anti-stress effect by reverting these peripheral stress parameters at a dose of 40 mg/kg p.o.