1217267-67-8

Basic information

• Product Name: methyl {(2S,4R)-1-{(1R)-4-methyl-1-[6-(trifluoromethyl)-3-pyridinyl]pentyl}-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate
• CAS NO: 1217267-67-8
• Molecular Weight: 530.554
• Mol File: 1217267-67-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl {(2S,4R)-1-{(1R)-4-methyl-1-[6-(trifluoromethyl)-3-pyridinyl]pentyl}-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl {(2S,4R)-1-{(1R)-4-methyl-1-[6-(trifluoromethyl)-3-pyridinyl]pentyl}-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate(1217267-67-8)
• EPA Substance Registry System: methyl {(2S,4R)-1-{(1R)-4-methyl-1-[6-(trifluoromethyl)-3-pyridinyl]pentyl}-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate(1217267-67-8)

Safety Data

• Hazardous Substances Data: 1217267-67-8(Hazardous Substances Data)

Upstream product

• 884602-78-2 (+)-methyl {(2S,4R)-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetate 
• 107-82-4 i-pentyl bromide 
• 386704-12-7 6-(trifluoromethyl)pyridine-3-carbaldehyde 

Downstream Products

• 1217267-68-9 {(2S,4R)-1-{(1R)-4-methyl-1-[6-(trifluoromethyl)-3-pyridinyl]pentyl}-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl}acetic acid 
• 1217267-66-7 {(2S,4R)-1-{(1R)-4-methyl-1-[6-(trifluoromethyl)-3-pyridinyl]pentyl}-2-[4-(trifluoromethyl)phenyl]-4-piperidinyl} acetic acid 

Relevant articles and documents

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This Letter details the SAR of a novel series of piperidine-derived γ-secretase modulators. Compound 10h was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42, increase Aβ38 and have no effect on Aβ40 levels.