121727-23-9

Upstream product

• 121727-22-8 3-Hydroxy-1-(4-nitrobenzoyloxy)propanone 
• 119555-33-8 (S)-1,2-O-isopropylidene glycerol 4-nitrobenzoate 
• 122-04-3 4-nitro-benzoyl chloride 
• 106268-95-5 (R)-glycidyl 4-nitrobenzoate 
• 902-47-6 p-nitrobenzoic anhydride 
• 56-81-5 glycerol 

Downstream Products

• 1262956-67-1 (2R)-2,3-bis(nitrooxy)propyl 4-nitrobenzoate 
• 115459-65-9 oxiran-2-ylmethyl-4-nitrobenzoate 
• 121727-24-0 (S)-1-(4-Nitrobenzoyloxy)-3-tosyloxy-2-propanol 

Relevant academic research and scientific papers

NITRIC OXIDE RELEASING NAPROXEN

The present invention relates to a novel nitric oxide releasing naproxen derivative, its use for the treatment of diseases associated with pain and inflammation. This NO releasing naproxen derivative shows a surprisingly improved gastrointestinal safety a

Lipase-mediated desymmetrization of glycerol with aromatic and aliphatic anhydrides

Chirazyme L-2 (Candida antarctica) catalyzed esterification of glycerol with aromatic and aliphatic anhydrides in 1,4-dioxane is described. All the aromatic monoacylglycerols (MAGs) were produced as (R)-enantiomers, while aliphatic MAGs were obtained either as racemic mixtures or the (S)-enantiomers. The influence of substituted aromatic rings, chain length, and presence of a conjugated double bond in the acyl donor moiety on the enantiotopic selectivity as well as the efficiency of the enzyme was studied.

Enatioselective Microbial Reduction of Monoesters of 1,3-Dihydroxypropanone: Synthesis of (S)- and (R)-1,2-O-Isopropylideneglycerol

The reduction of 3-benzoyloxy-1-hydroxypropanone with bakers' yeast proceeds enantioselectively to afford (S)-3-benzoyloxy-1,2-propanediol, which may be further converted into (S)-(benzoyloxymethyl)oxirane.The bioreduction with fermenting yeast of 1-acetoxy-3-benzyloxypropanones gives (R)-1-benzyloxy-3-acetoxy-2-propanol which can be used for the preparation of both (S)- and (R)-1,2-O-isopropylideneglycerol.