1217272-70-2

Upstream product

• 58-55-9 theophylline 
• 696-62-8 para-iodoanisole 
• 5720-07-0 4-methoxyphenylboronic acid 

Downstream Products

• 1217272-87-1 N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)benzenesulfonamide 
• 1217272-90-6 N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)-4-methylbenzenesulfonamide 
• 1217272-84-8 N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)methanesulfonamide 
• 1217272-79-1 methyl 4-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenylcarbamate 
• 1217272-72-4 8-(4-(dimethylamino)phenyl)-7-(4-methoxyphenyl)-1,3-dimethyl-1H-purine-2,6-(3H,7H)-dione 
• 1217272-76-8 N-(4-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)acetamide 
• 1307885-34-2 N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-2-yl)methanesulfonamide 
• 1307885-33-1 N-(3-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)phenyl)methanesulfonamide 

Relevant academic research and scientific papers

Copper nanoparticle-doped silica cuprous sulfate as a highly efficient and reusable heterogeneous catalysis for N-arylation of nucleobases and N-heterocyclic compounds

A facile and simple protocol for Ullmann-type N-arylation of nucleobases with aryl halides is described using copper nanoparticle-doped silica cuprous sulfate (CN-DSCS) as a new and efficient heterogeneous catalysis. In this method, treatment of various n

Fluorescent phosphoinositide 3-kinase inhibitors suitable for monitoring of intracellular distribution

The monitoring of the drug behavior and distribution in biological system can provide information whether drug reaches its desired target, and a biological rationale for the design of new therapeutics. We have developed a family of potent fluorescent PI3K

Development of new fluorescent xanthines as kinase inhibitors

"Chemical Equation Presented" An efficient and versatile synthetic approach for the preparation of highly substituted xanthine derivatives has been developed by a combination of direct N7- and C8-arylation. With this method, diverse xanthine analogues were prepared and potent kinase inhibitors could be identified. For example, compound 8a inhibits PI3Ks and proliferation in T47D tumor cells. In addition, these xanthine-based kinase inhibitors exhibited significant fluorescence emission in a concentration- dependent response.