1217343-53-7Relevant articles and documents
RAPAMYCIN CARBONIC ESTER ANALOGUES, PHARMACEUTICAL COMPOSITIONS, PREPARATIONS AND USES THEREOF
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, (2011/08/08)
Rapalogs of formula I, pharmaceutically acceptable salts, pharmaceutical compositions, and preparation methods and uses thereof. The rapalogs have the structure of formula I and can be used as an anti-tumor medicament. Comparing with rapamycin, the rapalogs of the present invention exhibit enhanced water solubility, and improved pharmacological and pharmacokinetic properties by introducing a hydrophilic and polar group such as a hydroxyl.