1217356-86-9Relevant academic research and scientific papers
Heterogeneous Pd/C-catalyzed, ligand free Suzuki–Miyaura coupling reaction furnishes new p-terphenyl derivatives
Avula, Satya Kumar,Rehman, Najeeb Ur,Anwar, Muhammad U.,Aalthani, Ghanim,Csuk, Rene,Al-Harrasi, Ahmed
, p. 1 - 5 (2020)
A series of new para-terphenyls derivatives have been efficiently synthesized by a ligand-free heterogeneous Pd/C-catalyzed two-fold Suzuki–Miyaura coupling reaction. Methyl 5-bromo-2-iodobenzoate was selected to react with a variety of different aryl boronic acids (2a-i). Nine new p-terphenyl derivatives (3a–i) were prepared and the structures were confirmed by several analytical techniques including infrared, spectroscopy, 1H and 13C NMR spectroscopy, mass spectrometry, and in the case of compound 3 b, by X-ray diffraction method. The new derivatives were obtained in very good yields (78–91percent). This synthetic facile route is envisioned to improve the preparation of p-terphenyl-based natural products.
