1217453-91-2

Basic information

• Product Name: (r)-1-(2,6-difluorophenyl)ethanaMine-hcl
• Synonyms: (r)-1-(2,6-difluorophenyl)ethanaMine-hcl;(r)-1-(2,6-difluorophenyl)ethaneaMine hcl;(1R)-1-(2,6-DIFLUOROPHENYL)ETHYLAMINE
• CAS NO: 1217453-91-2
• Molecular Formula: C₈H₉F₂N
• Molecular Weight: 193.6215064
• Mol File: 1217453-91-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (r)-1-(2,6-difluorophenyl)ethanaMine-hcl(CAS DataBase Reference)
• NIST Chemistry Reference: (r)-1-(2,6-difluorophenyl)ethanaMine-hcl(1217453-91-2)
• EPA Substance Registry System: (r)-1-(2,6-difluorophenyl)ethanaMine-hcl(1217453-91-2)

Safety Data

• Hazardous Substances Data: 1217453-91-2(Hazardous Substances Data)

Usage

General Description

The chemical "(r)-1-(2,6-difluorophenyl)ethanaMine-hcl" is a salt form of a specific enantiomer of 1-(2,6-difluorophenyl)ethanamine. (r)-1-(2,6-difluorophenyl)ethanaMine-hcl is a derivative of phenethylamine and is used as a reagent in chemical synthesis. It is often used in the production of pharmaceuticals and research chemicals. The "hcl" in the name indicates that the compound is in hydrochloride salt form, which is a common way of preparing a compound for pharmaceutical use. This particular enantiomer of 1-(2,6-difluorophenyl)ethanamine has specific properties and uses that are distinct from its other enantiomers.

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Relevant articles and documents

Stereoselective amination of racemic sec-alcohols through sequential application of laccases and transaminases

A one-pot/two-step bienzymatic asymmetric amination of secondary alcohols is disclosed. The approach is based on a sequential strategy involving the use of a laccase/TEMPO catalytic system for the oxidation of alcohols into ketone intermediates, and their following transformation into optically enriched amines by using transaminases. Individual optimizations of the oxidation and biotransamination reactions have been carried out, studying later their applicability in a concurrent process. Therefore, 17 racemic (hetero) aromatic sec-alcohols with different substitutions in the aromatic ring have been converted into enantioenriched amines with good to excellent selectivities (90-99% ee) and conversion values (67-99%). The scalability of the process was also demonstrated when two different amine donors were used in the transamination step, such as isopropylamine and cis-2-buten-1,4-diamine. Satisfyingly, both sacrificial amine donors can shift the equilibrium toward the amine formation, leading to the corresponding isolated enantioenriched amines with good to excellent results.

Transaminases applied to the synthesis of high added-value enantiopure amines

Critical parameters affecting the stereoselective amination of (hetero)aromatic ketones using transaminases have been studied, such as temperature, pH, substrate concentration, cosolvent, and source and percentage of amino donor, to further optimize the production of enantiopure amines using both (S)- and (R)-selective biocatalysts from commercial suppliers. Interesting enantiopure amino building blocks have been obtained, overcoming some limitations of traditional chemical synthetic methods. Representative processes were scaled up, affording halogenated and heteroaromatic amines in enantiomerically pure form and good isolated yields.