1217554-48-7

Basic information

• Product Name: 3-((4-methoxyphenyl)buta-1,3-diyn-1-yl)thiophene
• Synonyms: 3-((4-methoxyphenyl)buta-1,3-diyn-1-yl)thiophene
• CAS NO: 1217554-48-7
• Molecular Weight: 238.31
• Mol File: 1217554-48-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3-((4-methoxyphenyl)buta-1,3-diyn-1-yl)thiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((4-methoxyphenyl)buta-1,3-diyn-1-yl)thiophene(1217554-48-7)
• EPA Substance Registry System: 3-((4-methoxyphenyl)buta-1,3-diyn-1-yl)thiophene(1217554-48-7)

Safety Data

• Hazardous Substances Data: 1217554-48-7(Hazardous Substances Data)

Upstream product

• 67237-53-0 3-ethynylthiophene 
• 768-60-5 4-methoxyphenylacetylen 
• 81294-09-9 3-(2,2-dibromoethenyl)-thiophene 
• 33675-51-3 2-(bromoethynyl)thiophene 
• 2227-57-8 3-(4-methoxyphenyl)propynoic acid 

Relevant articles and documents

Synthesis of Unsymmetrical 1,3-Diynes via Pd/Cu-Catalyzed Cross-Coupling of Terminal Alkynes at Room Temperature

A facile and practical synthetic route of unsymmetrical 1,3-diynes via the PdCl/CuI catalyzed oxidative coupling of two different terminal alkynes has been developed by using 3-(diphenylphosphino)propanoic acid as a ligand in the presence of oxygen. This system is suitable for not only aromatic alkynes but also heteroaromatic and aliphatic alkynes which were transformed into the corresponding unsymmetrical 1,3-diynes in moderate to good yields at room temperature. Moreover, the unsymmetrical 1,3-diynes were also obtained on a multi-gram scale. Mechanistic studies suggest that oxygen plays a key role in the catalytic cycles.

A co-operative Ni-Cu system for Csp-Csp and Csp-Csp2 cross-coupling providing a direct access to unsymmetrical 1,3-diynes and en-ynes

An efficient cross-coupling of alkynes with alkynyl and alkenyl halides catalysed by a Ni-Cu system without any ligand has been achieved. The reaction is suggested to proceed by Ni(0) catalysis assisted by Cu(i). A series of functionalised diaryl, aryl-alkyl, aryl-heteroaryl, diheteroaryl 1,3-di-ynes and en-ynes are obtained in high yields.

Copper-catalyzed decarboxylative cross-coupling of propiolic acids and terminal alkynes

A copper-catalyzed decarboxylative cross-coupling reaction of propiolic acids with terminal alkynes is developed leading to unsymmetric 1,3-conjugated diynes under mild conditions. This method provides a novel decarboxylative cross-coupling for sp-sp bond formation. Compared to organic halides, only carbon dioxide is produced as by-products in this approach.