1217554-49-8

Basic information

• Product Name: 1-(3,4-dimethoxyphenyl)-4-phenylbuta-1,3-diyne
• Synonyms: 1-(3,4-dimethoxyphenyl)-4-phenylbuta-1,3-diyne
• CAS NO: 1217554-49-8
• Molecular Weight: 262.308
• Mol File: 1217554-49-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(3,4-dimethoxyphenyl)-4-phenylbuta-1,3-diyne(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-dimethoxyphenyl)-4-phenylbuta-1,3-diyne(1217554-49-8)
• EPA Substance Registry System: 1-(3,4-dimethoxyphenyl)-4-phenylbuta-1,3-diyne(1217554-49-8)

Safety Data

• Hazardous Substances Data: 1217554-49-8(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 91-16-7 1,2-dimethoxybenzene 
• 16900-79-1 2-methyl-6-phenylhexa-3,5-diyn-2-ol 
• 5460-32-2 1-iodo-3,4-dimethoxybenzene 
• 22511-06-4 3,4-dimethoxyphenylpropiolic acid 

Relevant articles and documents

One-pot synthesis of unsymmetrical 1,3-butadiyne derivatives and their application in the synthesis of unsymmetrical 2,5-diarylthiophenes

A one-pot protocol was developed for the synthesis of unsymmetrical 1,3-butadiynes. The procedure is based on two sequential reactions: deprotection of R–C≡C–C≡C– C(Me)2OH derivatives in a retro-Favorskii reaction to furnish a terminal 1,3-butadiyne compound, which reacted with aryl iod-ides in a Sonogashira-type cross-coupling reaction catalyzed by Pd(PPh3)4 and CuI, using TBAOH as activator and toluene as solvent under reflux for 10 min. We also studied in situ thiocycli-zation of 1,3-butadiynes, leading to unsymmetrical 2,5-diaryl-thiophenes. The principal features of this method are operational simplicity, good substrate scope, very fast reaction, and high yields.