22511-06-4

Basic information

• Product Name: 3-(3,4-DIMETHOXY-PHENYL)-PROPYNOIC ACID
• Synonyms: 3-(3,4-DIMETHOXY-PHENYL)-PROPYNOIC ACID;3-(3,4-Dimethoxyphenyl)propiolic acid;3,4-Dimethoxyphenylpropiolic acid
• CAS NO: 22511-06-4
• Molecular Formula: C₁₁H₁₀O₄
• Molecular Weight: 206.1947
• EINECS: -0
• Mol File: 22511-06-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 154℃
• Boiling Point: 369℃
• Flash Point: 146℃
• Appearance: /
• Density: 1.27
• CAS DataBase Reference: 3-(3,4-DIMETHOXY-PHENYL)-PROPYNOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-DIMETHOXY-PHENYL)-PROPYNOIC ACID(22511-06-4)
• EPA Substance Registry System: 3-(3,4-DIMETHOXY-PHENYL)-PROPYNOIC ACID(22511-06-4)

Safety Data

• Hazardous Substances Data: 22511-06-4(Hazardous Substances Data)

Upstream product

• 99873-50-4 2,3-dibromo-3-(3',4'-dimethoxy)-phenyl ethyl propanoate 
• 20583-78-2 3,4-dimethoxy-cinnamic acid ethyl ester 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 124-38-9 carbon dioxide 
• 4302-52-7 4-ethynylveratrole 
• 5401-66-1 2,3-Dibromo-3-(3,4-dimethoxy-phenyl)-propionic acid methyl ester 
• 30461-77-9 methyl 3,4-dimethoxycinnamate 
• 2316-26-9 3,4-dimethoxycinnamic acid 
• 14737-89-4 3,4-dimethoxy-trans-cinnamic acid 
• 20583-78-2 ethyl (E)-3,4-dimethoxycinnamate 
• 62497-24-9 (3,4-dimethoxyphenyl)propynoic acid methyl ester 

Downstream Products

• 25936-93-0 6,7-dimethoxy-1-(3',4'-dimethoxyphenyl)naphthalene-2,3-dicarboxylic anhydride 
• 4302-52-7 4-ethynylveratrole 
• 71616-34-7 ethyl 3-(3',4'-dimethoxyphenyl)propiolate 
• 144223-81-4 5,7-dihydroxy-4-(3,4-dihydroxyphenyl)-chromen-2-one 
• 35582-80-0 4-(3,4-dimethoxy-phenyl)-7-methoxy-chroman-2-one 
• 1259079-11-2 (±)-4-(3,4-dimethoxyphenyl)-7,8-dihydroxy-3,4-dihydrocoumarin 
• 35582-78-6 (±)-4-(3,4-dimethoxyphenyl)-7-hydroxy-3,4-dihydrocoumarin 
• 1431959-51-1 N-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)-3-(3,4-dimethoxyphenyl)propiolamide trifluoroacetate 
• 185033-52-7 7,8-dihydroxy-4-(3',4'-dimethoxyphenyl)-2H-1-chromen-2-one 
• 23982-43-6 4-(3',4'-dimethoxyphenyl)-7-hydroxycoumarin 

Relevant articles and documents

Synthesis and biological evaluation of 4-arylcoumarins as potential anti-Alzheimer's disease agents

Alzheimer's disease (AD) is a progressive neurological degenerative disease that has complex pathogenesis. A variety of studies in humans indicate that several enzymes inhibitors can be useful in the treatment of AD, including acetylcholinesterase (AchE), butyrylcholinesterase (BuChE) and monoamine oxidase (MAO). Various substituted 4-arylcoumarin derivatives were synthesised, and their activity in vitro were investigated, including AChE/BuChE inhibitory activity, MAO inhibitory activity, and antioxidant activity. Most of the compounds were found to exhibit high inhibitory activity, and individual compounds have extremely excellent activities. Therefore 4-arylcoumarins provides an idea for drugs design for the development of therapeutic or preventive agents for AD.

Preparation method of neoflavonoids

The invention relates to the field of chemical synthesis, in particular to a preparation method of neoflavonoids. The preparation method is characterized by comprising the following steps of using substituted benzaldehyde as an initial raw material to be reacted with malonic acid to generate a substituted phenylacrylic acid compound; performing an addition reaction, an elimination reaction and the like on the substituted phenylacrylic acid compound, or performing acetylation so as to protect a phenolic hydroxyl group, then performing a bromination reaction and the elimination reaction so as to synthesize the substituted phenylpropiolic acid compound ; and using montmorillonite K-10 after being acidulated by sulfuric acid as a catalyst, enabling the substituted phenylpropiolic acid compound and a phenolic compound to perform a heating reaction so as to generate the neoflavonoids. Compared with the prior art, the preparation method of the neoflavonoids, disclosed by the invention, has the characteristics that raw materials are cheap, and easy to obtain, the operation is simple, the catalyst can be recovered for use, and the method is environmentally-friendly, the post-treatment is simple, and the production cost is low, and the method has a high popularization and application value.

Synthesis and antimicrobial activities of 4-aryl-3,4-dihydrocoumarins and 4-arylcoumarins

A new series of 4-aryl-3,4-dihydrocoumarins and 4-arylcoumarins were synthesized by the reaction of substituted cinnamic acids and 3-arylpropiolic acid with the corresponding phenols. These compounds were evaluated for antibacterial activity in vitro. The