1217633-31-2Relevant academic research and scientific papers
Synthetic strategy for side chain mono-N-alkylation of Fmoc-amino acids promoted by molecular sieves
Monfregola, Luca,De Luca, Stefania
, p. 981 - 990 (2011)
A new synthetic strategy to alkylate amino groups under mild conditions has been developed. It utilizes only 4 A molecular sieves as base in order to promote the N-alkylation reaction, in presence of the appropriate alkyl halide. The methodology was validated by the simple and efficient side-chain N-alkylation of o-Ns-protected Fmoc-amino acid. One of them was introduced as building block into a peptide sequence, thus allowing the preparation of site-specific alkylated peptide molecules. Springer-Verlag 2010.
