1217651-75-6

Basic information

• Product Name: (S)-2-(4-CHLOROPHENYL)PYRROLIDINE
• Synonyms: (S)-2-(4-CHLOROPHENYL)PYRROLIDINE;(2S)-2-(4-chlorophenyl)pyrrolidine
• CAS NO: 1217651-75-6
• Molecular Formula: C₁₀H₁₂ClN
• Molecular Weight: 181.66
• Mol File: 1217651-75-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 269℃
• Flash Point: 117℃
• Appearance: /
• Density: 1.129
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.58±0.10(Predicted)
• CAS DataBase Reference: (S)-2-(4-CHLOROPHENYL)PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(4-CHLOROPHENYL)PYRROLIDINE(1217651-75-6)
• EPA Substance Registry System: (S)-2-(4-CHLOROPHENYL)PYRROLIDINE(1217651-75-6)

Safety Data

• Hazardous Substances Data: 1217651-75-6(Hazardous Substances Data)

Usage

General Description

(S)-2-(4-chlorophenyl)pyrrolidine is a chemical compound that belongs to the class of pyrrolidine derivatives. It is a chiral compound, meaning that it has a non-superimposable mirror image, or enantiomer. (S)-2-(4-CHLOROPHENYL)PYRROLIDINE is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The 4-chlorophenyl group attached to the pyrrolidine ring provides the compound with its specific chemical and biological properties, making it useful in various fields of research and development. Additionally, the pyrrolidine ring structure itself is known for its stability and unique characteristics, contributing to the versatile and important nature of this chemical.

Upstream product

• 1228560-89-1 (S)-2-(4-chloro-phenyl)-pyrrolidine hydrochloride 
• 1218989-53-7 (S)-1-((S)-2-methyl-propane-2-sulfinyl)-2-(4-chlorophenyl)-pyrrolidine 
• 22217-78-3 5-(4-chlorophenyl)-3,4-dihydro-2H-pyrrole 
• 1354651-37-8 tert-butyl (4-(4-chlorophenyl)-4-oxobutyl)carbamate 

Relevant articles and documents

Zinc-Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2-Aryl-Substituted Pyrrolidines as Pharmaceutical Building Blocks

The first successful enantioselective hydrosilylation of cyclic imines promoted by a chiral zinc complex is reported. In situ generated zinc-ProPhenol complex with silane afforded pharmaceutically relevant enantioenriched 2-aryl-substituted pyrrolidines in high yields and with excellent enantioselectivities (up to 99% ee). The synthetic utility of presented methodology is demonstrated in an efficient synthesis of the corresponding chiral cyclic amines, being pharmaceutical drug precursors to the Aticaprant and Larotrectinib. (Figure presented.).

A General Approach to Stereospecific Cross-Coupling Reactions of Nitrogen-Containing Stereocenters

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PROCESS FOR SYNTHESIS OF 2-SUBSTITUTED PYRROLIDINES AND PIPERADINES

The present invention provides a highly efficient, versatile one-step process for asymmetric synthesis of either diastereomer of 2-substituted pyrrolidines from a single starting material with excellent yields and high diastereoselectivety. Also provided is a method for the asymmetric synthesis of both diastereomers of 2-substituted piperidines with good yields and excellent diastereoselectivety. Diasteroselectivity is controlled effectively by choice of reducing agent.