1217788-99-2 Usage
Description
(S)-2-(2-CHLOROPHENYL)PYRROLIDINE is a heterocyclic organic compound belonging to the class of pyrrolidine compounds. It features a five-membered ring structure with four carbon atoms and one nitrogen atom, and is distinguished by the attachment of a chlorophenyl group to the pyrrolidine ring. This unique structure and its chemical and physical properties make it a valuable compound for pharmaceutical research, drug development, and various industrial applications.
Uses
Used in Pharmaceutical Research and Drug Development:
(S)-2-(2-CHLOROPHENYL)PYRROLIDINE is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Chemical Industry:
(S)-2-(2-CHLOROPHENYL)PYRROLIDINE is utilized as a versatile building block in the chemical industry for the production of various organic compounds. Its specific chemical properties make it suitable for use in the synthesis of specialty chemicals and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 1217788-99-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,7,7,8 and 8 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1217788-99:
(9*1)+(8*2)+(7*1)+(6*7)+(5*7)+(4*8)+(3*8)+(2*9)+(1*9)=192
192 % 10 = 2
So 1217788-99-2 is a valid CAS Registry Number.
1217788-99-2Relevant articles and documents
Zinc-Catalyzed Asymmetric Hydrosilylation of Cyclic Imines: Synthesis of Chiral 2-Aryl-Substituted Pyrrolidines as Pharmaceutical Building Blocks
W?glarz, Izabela,Michalak, Karol,Mlynarski, Jacek
supporting information, p. 1317 - 1321 (2020/12/09)
The first successful enantioselective hydrosilylation of cyclic imines promoted by a chiral zinc complex is reported. In situ generated zinc-ProPhenol complex with silane afforded pharmaceutically relevant enantioenriched 2-aryl-substituted pyrrolidines in high yields and with excellent enantioselectivities (up to 99% ee). The synthetic utility of presented methodology is demonstrated in an efficient synthesis of the corresponding chiral cyclic amines, being pharmaceutical drug precursors to the Aticaprant and Larotrectinib. (Figure presented.).
A General Approach to Stereospecific Cross-Coupling Reactions of Nitrogen-Containing Stereocenters
Binayeva, Meruyert,Biscoe, Mark R.,Diane, Mohamed,Ma, Xinghua,Ralph, Glenn,Wang, Chao-Yuan,Zhao, Haoran,Zhao, Shibin
supporting information, p. 781 - 791 (2020/03/11)
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