1217792-81-8

Basic information

• Product Name: C₁₆H₂₀F₃N₃O₄
• CAS NO: 1217792-81-8
• Molecular Weight: 375.348
• Mol File: 1217792-81-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₂₀F₃N₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₂₀F₃N₃O₄(1217792-81-8)
• EPA Substance Registry System: C₁₆H₂₀F₃N₃O₄(1217792-81-8)

Safety Data

• Hazardous Substances Data: 1217792-81-8(Hazardous Substances Data)

Upstream product

• 400-74-8 2-Fluoro-5-nitrobenzotrifluoride 
• 122536-76-9 3(S)-(tert-butoxycarbonylamino)pyrrolidine 

Downstream Products

• 1291057-79-8 1-benzo[b]thiophen-3-yl-3-[1-(4-nitro-2-trifluoromethylphenyl)-(S)-pyrrolidin-3-ylamino]propan-1-one 
• 1217792-73-8 1-(4-nitro-2-trilfluoromethylphen-3-yl)-(S)-pyrrolidin-3-amine 

Relevant articles and documents

Novel benzo[ b ]thiophene derivatives as new potential antidepressants with rapid onset of action

We report benzo[b]thiophene derivatives synthesized according to a dual strategy. 8j, 9c, and 9e with affinity values toward 5-HT7R and 5-HTT were selected to probe their antidepressant activity in vivo using the forced swimming text (FST). The results showed significant antidepressant activity after chronic treatment. 9c was effective in reducing the immobility time in FST even after acute treatment. These findings identify these compounds as a new class of antidepressants with a rapid onset of action.