1217864-59-9Relevant academic research and scientific papers
Identification and SAR of novel pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1)
Pescatore, Giovanna,Branca, Danila,Fiore, Fabrizio,Kinzel, Olaf,Bufi, Laura Llauger,Muraglia, Ester,Orvieto, Federica,Rowley, Michael,Toniatti, Carlo,Torrisi, Caterina,Jones, Philip
, p. 1094 - 1099 (2010)
Herein we describe the discovery of a novel series of pyrrolo[1,2-a]pyrazin-1(2H)-one PARP inhibitors. Optimization led to compounds that display excellent PARP-1 enzyme potency and inhibit the proliferation of BRCA deficient cells in the low double-digit
