121789-63-7

Upstream product

• 22775-37-7 3,5-dichloro-2-methoxybenzoic acid 
• 64122-23-2 methyl 3,5-dichloro-2-methoxybenzoate 
• 121789-29-5 1-(3,5-Dichlor-2-methoxyphenyl)-3-(1,3-dioxan-2-yl)-1-propanon 
• 1198777-56-8 N-(3,5-dichloro-2-methoxybenzylidene)-4-methylbenzenesulfonamide 
• 90-60-8 3,5-dichlorosalicyclaldehyde 
• 1198777-59-1 N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide 
• 1198777-63-7 N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide 
• 1198777-66-0 2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole 
• 76008-04-3 3,5-dichloro-2-methoxybenzaldehyde 
• 121789-41-1 1-(3,5-Dichlor-2-methoxyphenyl)-1,4-butandion 
• 5213-08-1 3,5-dichloro-2-methoxybenzoyl chloride 
• 121789-57-9 2,3,4-tribromo-5-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole 
• 69640-33-1 2-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole 

Relevant academic research and scientific papers

Silver(I)-catalyzed route to pyrroles: Synthesis of halogenated pseudilins as allosteric inhibitors for myosin atpase and x-ray crystal structures of the protein-inhibitor complexes

The pentahalogenated 2-arylpyrrole-type alkaloids pentabromopseudilin and pentachloropseudilin represent a new class of isoform-specific allosteric inhibitors of myosin ATPase. Herein, we describe an application of the silver(I)-catalyzed cycloisomerizati

MEANS FOR TREATING MYOSIN-RELATED DISEASES

The present invention provides a method of designing a modulator of a myosin, the method comprising molecular modeling of a compound such that the modeled compound interacts with at least three amino acid residues of said myosin, said residues being selec

Total synthesis of pentabromo- and pentachloropseudilin, and synthetic analogues-allosteric inhibitors of myosin ATPase

Stopping myo: The total syntheses of the title compounds have been achieved using a highly efficient silver(I)- catalyzed cyclization of N-tosyl-homopropargylamines. The pseudilin derivatives represent a novel class of myosin inhibitors. A new allosteric

Marine Bacteria, I. - Synthesis of Pentabromopseudiline, a Cytotoxic Phenylpyrrole from Alteromonas luteo-violaceus

A new synthesis of 2,3,4-tribromo-5-(3,5-dibromo-2-hydroxyphenyl)pyrrole (1a, pentabromopseudiline), an antibiotic, enzymeinhibitory and cytotoxic active constituent of the marine bacterium Alteromonas luteo-violaceus, is described.For investigation of structure-activity relationships further 2-phenylpyrroles are investigated.Key step in their synthesis is the Grignard reaction of 2-(1,3-dioxan-2-yl)ethylmagnesium bromide (9d) with benzoyl chlorides yielding γ-phenyl-γ-ketoaldehydes 24, and the Paal-Knorr cyclisation of the latter. - Key Words: Alteromonas luteo-violaceus / Bromopyrrole / Marine bacteria / Pentabromopseudiline