76008-04-3

Usage

Uses

Used in Environmental Analysis:
3,5-Dichloro-2-methoxybenzaldehyde (SALTDATA: FREE) is used as a reagent for the detection of magnesium in drinking water by fluorometry. This application is crucial for ensuring water quality and safety, as magnesium is an essential mineral for human health but must be present within certain concentration limits.
In this context, the compound serves as a selective and sensitive fluorophore, enabling the accurate measurement of magnesium concentrations. The use of 3,5-dichloro-2-methoxybenzaldehyde (SALTDATA: FREE) in fluorometric assays provides a reliable and efficient method for monitoring magnesium levels in drinking water, contributing to the maintenance of public health and environmental standards.

InChI:InChI=1/C8H6Cl2O2/c1-12-8-5(4-11)2-6(9)3-7(8)10/h2-4H,1H3

Upstream product

• 74-88-4 methyl iodide 
• 90-60-8 3,5-dichlorosalicyclaldehyde 
• 74-83-9 methyl bromide 

Downstream Products

• 861814-51-9 (3,5-dichloro-2-methoxy-phenyl)-[9]phenanthryl-methanol 
• 505061-49-4 9-(3,5-dichloro-2-methoxyphenylmethylene)-2,4,5,7-tetranitrofluorene 
• 1198777-56-8 N-(3,5-dichloro-2-methoxybenzylidene)-4-methylbenzenesulfonamide 
• 1198777-59-1 N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide 
• 1198777-63-7 N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzene-sulfonamide 
• 1198777-66-0 2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole 
• 69640-33-1 2-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole 
• 69640-34-2 2,3,4-trichloro-5-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole 
• 69640-38-6 2,4-dichloro-6-(3,4,5-trichloro-1H-pyrrol-2-yl)phenol 
• 121789-57-9 2,3,4-tribromo-5-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole 
• 121789-63-7 2,3,4-tribromo-5-(3,5-dichloro-2-hydroxyphenyl)-1H-pyrrole 
• 1158948-11-8 2,3,4-triiodo-5-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole 

Relevant academic research and scientific papers

A real-time fluorescent sensor specific to Mg2+: Crystallographic evidence, DFT calculation and its use for quantitative determination of magnesium in drinking water

An off-the-shelf fluorescence turn-on Mg2+ chemosensor 3,5-dichlorosalicylaldehyde (BCSA) was rationally designed and developed. This proposed sensor works based on Mg2+-induced formation of the 2:1 BCSA-Mg2+ complex. The coordination of BCSA to Mg2+ increases its structural rigidity generating a chelation-enhanced fluorescence (CHEF) effect which was confirmed by single crystal XRD studies of the BCSA-Mg2+ complex and TD/DFT calculations. This sensor exhibits high sensitivity and selectivity for the quantitative monitoring of Mg2+ with a wide detection range (0-40 μM), a low detection limit (2.89 × 10-7 mol L-1) and a short response time (2+. Consequently, this fluorescent sensor can be utilized to monitor Mg2+ in real time within actual samples from drinking water. This journal is

As neuroprotective agents of pharmaceutical compounds

The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.

Optimization of a binding fragment targeting the “enlarged methionine pocket” leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors

Potent inhibitors of Trypanosoma brucei methionyl-tRNA synthetase were previously designed using a structure-guided approach. Compounds 1 and 2 were the most active compounds in the cyclic and linear linker series, respectively. To further improve cellular potency, SAR investigation of a binding fragment targeting the “enlarged methionine pocket” (EMP) was performed. The optimization led to the identification of a 6,8-dichloro-tetrahydroquinoline ring as a favorable fragment to bind the EMP. Replacement of 3,5-dichloro-benzyl group (the EMP binding fragment) of inhibitor 2 using this tetrahydroquinoline fragment resulted in compound 13, that exhibited an EC50 of 4?nM.

Metabolic investigation on ZL006 for the discovery of a potent prodrug for the treatment of cerebral ischemia

4-((3,5-Dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoic acid (ZL006, 1) is a small-molecular inhibitor of the nNOS/PSD-95 interaction, that is under preclinical evaluation stage for cerebral ischemia. However, the fast metabolism and low permeability acr

Silver(I)-catalyzed route to pyrroles: Synthesis of halogenated pseudilins as allosteric inhibitors for myosin atpase and x-ray crystal structures of the protein-inhibitor complexes

The pentahalogenated 2-arylpyrrole-type alkaloids pentabromopseudilin and pentachloropseudilin represent a new class of isoform-specific allosteric inhibitors of myosin ATPase. Herein, we describe an application of the silver(I)-catalyzed cycloisomerizati

NITROGENOUS CYCLIC KETONE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

A novel compound represented by the formula (I): wherein rings A and B each represents an optionally substituted aromatic ring, or rings A and B may be bonded to each other through linking between bonds or substituents thereof to form a ring; ring C represents a nitrogenous saturated heterocycle optionally having one or more substituents besides the oxo (provided that 2,3-dioxopyrrolidine ring is excluded); R1 represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group; and-------- indicates a single bond or a double bond. It has high antagonistic activity against a tachykinin receptor, especially an SP receptor.