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Upstream product

• 5472-84-4 3-hydroxy-phenalen-1-one 
• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 109-77-3 malononitrile 

Relevant academic research and scientific papers

Copper ferrite nanoparticles: An efficient and reusable nanocatalyst for a green one-pot, three-component synthesis of spirooxindoles in water

A green reaction of isatins, active cyanomethanes, and cyclic 1,3-dicarbonyl derivatives for the efficient and simple one-pot three-component synthesis of spirooxindole fused heterocycles in refluxing water by use of magnetically recoverable and reusable catalyst is reported. The features of this procedure are, the use of magnetically recoverable and reusable catalyst, mild reaction conditions, high to excellent product yields, operational simplicity, and easy workup procedures. Most importantly of all, easy magnetic separation of the catalyst eliminates the requirement of catalyst filtration after completion of the reaction. Furthermore, the catalyst remained highly active even after 5 repeated uses.

Clean synthesis of spiro[indole-3,8′-phenaleno[1,2-b]pyran]-9′- carbonitriles and spiro[indole-3,4′-pyrano[4,3-b]pyran]-3′- carbonitriles by one-pot, three-component reactions

(Chemical Equation Presented) An environmentally benign three-component reaction in aqueous media has been reported for the synthesis of spiro[indole-3,8′-phenaleno[1,2-b]pyran]-9′-carbonitriles and spiro[indole-3,4′-pyrano[4,3-b]pyran]-3′-carbonitriles.

Efficient one-pot synthesis of spirooxindole derivatives by ethylenediamine diacetate catalyzed reactions in water

A simple and efficient one-pot synthetic approach was used for the preparation of biologically interesting spirooxindole derivatives by means of three-component reactions of isatins, malononitrile, and 1,3-dicarbonyl compounds catalyzed by ethylenediamine diacetate (EDDA) in an aqueous medium. This method is of great value because of its environmentally benign character, high yield, and easy handling. Georg Thieme Verlag Stuttgart - New York.