121795-05-9

Basic information

• Product Name: 2-tert-Butoxycarbonylamino-4-(ethoxy-methyl-phosphinoyl)-butyric acid 2,4,5-trichloro-phenyl ester
• CAS NO: 121795-05-9
• Molecular Weight: 488.732
• Mol File: 121795-05-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-tert-Butoxycarbonylamino-4-(ethoxy-methyl-phosphinoyl)-butyric acid 2,4,5-trichloro-phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-Butoxycarbonylamino-4-(ethoxy-methyl-phosphinoyl)-butyric acid 2,4,5-trichloro-phenyl ester(121795-05-9)
• EPA Substance Registry System: 2-tert-Butoxycarbonylamino-4-(ethoxy-methyl-phosphinoyl)-butyric acid 2,4,5-trichloro-phenyl ester(121795-05-9)

Safety Data

• Hazardous Substances Data: 121795-05-9(Hazardous Substances Data)

Upstream product

• 121795-10-6 2-t-butoxycarbonylamino-4-(ethoxymethylphosphinoyl)-L-butyric acid 
• 95-95-4 2,4,5-trichlorophenol 
• 16965-08-5 1,1-dimethylethyl 2,4,5-trichlorophenyl carbonate 

Downstream Products

• 35597-43-4 γ--D-α-aminobutyryl-L-alanyl-L-alanine 
• 35597-43-4 γ--L-α-aminobutyryl-L-alanyl-L-alanine 

Relevant articles and documents

Total synthesis and enzyme-substrate interaction of D-, DL-, and L-Phosphinotricine, 'bialaphos' (SF-1293) and its cyclic analogues

DL-Phosphonotricine (3) and its cyclic analogue (4) have been synthesized using the four-component isocyanide condensation of Ugi and Ugi-analogous three-component condensation, respectively. High selectivity of the enzyme-substrate interaction was established with the enzymes α-chymotrypsin, phosphodiesterase I, and alkaline mesintericopeptidase, as well as by separation of the racemic mixture to optical antipodes by the α-chymotripsin. The tripeptide 'bialaphos' (11) and its D-antipode (11a) have been synthesized by the method of activated esters, and the cyclic analogue (15) by the DCC method. It was found that the phospholane L-(5) and the tripeptide (18) exhibit anti-tumour activity.