121795-10-6

Basic information

• Product Name: 2-t-butoxycarbonylamino-4-(ethoxymethylphosphinoyl)-L-butyric acid
• Synonyms: 2-t-butoxycarbonylamino-4-(ethoxymethylphosphinoyl)-L-butyric acid
• CAS NO: 121795-10-6
• Molecular Weight: 309.299
• Mol File: 121795-10-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-t-butoxycarbonylamino-4-(ethoxymethylphosphinoyl)-L-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-t-butoxycarbonylamino-4-(ethoxymethylphosphinoyl)-L-butyric acid(121795-10-6)
• EPA Substance Registry System: 2-t-butoxycarbonylamino-4-(ethoxymethylphosphinoyl)-L-butyric acid(121795-10-6)

Safety Data

• Hazardous Substances Data: 121795-10-6(Hazardous Substances Data)

Upstream product

• 16965-08-5 1,1-dimethylethyl 2,4,5-trichlorophenyl carbonate 
• 121795-04-8 2-Amino-4-(ethoxy-methyl-phosphinoyl)-butyric acid; hydrochloride 

Downstream Products

• 35597-43-4 γ--L-α-aminobutyryl-L-alanyl-L-alanine 
• 121795-05-9 2-tert-Butoxycarbonylamino-4-(ethoxy-methyl-phosphinoyl)-butyric acid 2,4,5-trichloro-phenyl ester 

Relevant articles and documents

Total synthesis and enzyme-substrate interaction of D-, DL-, and L-Phosphinotricine, 'bialaphos' (SF-1293) and its cyclic analogues

DL-Phosphonotricine (3) and its cyclic analogue (4) have been synthesized using the four-component isocyanide condensation of Ugi and Ugi-analogous three-component condensation, respectively. High selectivity of the enzyme-substrate interaction was established with the enzymes α-chymotrypsin, phosphodiesterase I, and alkaline mesintericopeptidase, as well as by separation of the racemic mixture to optical antipodes by the α-chymotripsin. The tripeptide 'bialaphos' (11) and its D-antipode (11a) have been synthesized by the method of activated esters, and the cyclic analogue (15) by the DCC method. It was found that the phospholane L-(5) and the tripeptide (18) exhibit anti-tumour activity.