1218-75-3

Upstream product

• 1218-30-0 4'-bromo-2'-hydroxychalcone 
• 30186-18-6 4'-bromo-2'-hydroxyacetophenone 
• 100-52-7 benzaldehyde 
• 1218-30-0 (E)-1-(4-bromo-2-hydroxyphenyl)-3-phenylprop-2-en-1-one 
• 88034-35-9 pentacarbonyl{1-(1-methoxy-3(E)-phenyl-2-propenylidene)}chromium⁽⁰⁾ 
• 858855-11-5 5-bromo-2-iodo-phenol 

Downstream Products

• 1148-47-6 7-bromo-2-phenyl-4H-1-benzopyran-4-one 
• 1309652-14-9 7-bromo-2-phenyl-chroman-4-ol 
• 1309652-13-8 7-bromo-2-phenyl-chroman 

Relevant academic research and scientific papers

Palladium-Catalyzed [3+3] Annulation of Vinyl Chromium(0) Carbene Complexes through Carbene Migratory Insertion/Tsuji–Trost Reaction

Vinyl chromium(0) Fischer carbene complexes were employed as the source of π-allylic palladium species for catalytic [3+3] annulation under palladium catalysis. Mechanistically, this transformation is proposed to involve carbene migratory insertion and intramolecular Tsuji–Trost reaction as the key steps. Substituted six-membered heterocyclic flavonones and quinolines are obtained, depending on the nucleophilic functional group on the coupling partners.

BENZENE-FUSED 6-MEMBERED OXYGEN-CONTAINING HETEROCYCLIC DERIVATIVES OF BICYCLIC HETEROARYLS

The invention relates to new derivatives of formula I, wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a proliferative disease.