1218811-77-8

Basic information

• Product Name: 5-(4-methoxyphenyl)-2-[(4-methylphenyl)ethynyl]oxazole
• Synonyms: 5-(4-methoxyphenyl)-2-[(4-methylphenyl)ethynyl]oxazole
• CAS NO: 1218811-77-8
• Molecular Weight: 289.334
• Mol File: 1218811-77-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-methoxyphenyl)-2-[(4-methylphenyl)ethynyl]oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methoxyphenyl)-2-[(4-methylphenyl)ethynyl]oxazole(1218811-77-8)
• EPA Substance Registry System: 5-(4-methoxyphenyl)-2-[(4-methylphenyl)ethynyl]oxazole(1218811-77-8)

Safety Data

• Hazardous Substances Data: 1218811-77-8(Hazardous Substances Data)

Upstream product

• 1011-51-4 5-(4-methoxyphenyl)-1,3-oxazole 
• 766-97-2 4-n-methylphenylacetylene 

Relevant articles and documents

Copper-mediated direct cross-coupling of 1,3,4-oxadiazoles and oxazoles with terminal alkynes

Copper-mediated direct cross-coupling of 1, 3, 4-oxadiazoles and oxazoles with terminal alkynes has been reported. The transition-metal-mediated direct functionalization reactions of C-H bonds have attracted significant interest in modern organic chemistry. The mixture was heated at 120°C, and the slow addition of 1 hour of a solution of phenylacetylene in DMAc (1.0 mL) as then started. The cross-coupling using CuCl2/DMEDA system. Thus, the desired 2-alkynyl-5-aryloxazoles were obtained by performing the reaction in a higher ratio at 150°C with DMSO as solvent. The oxadiazoles with various substituents at the 2-position were also available for use. 4- Methyl-, 4-methoxy-, 4-trifluoromethyl-, and 4-chloro- phenyl-1, 3, 4-oxadiazoles coupled with 4-MeC5H4, to furnish compound.