121887-11-4

Usage

Uses

Used in Chemical Synthesis:
o-Aminophenol-d4 is used as a reagent for the synthesis of heterocyclic compounds and dyes. Its deuterated nature provides unique advantages in chemical reactions, such as improved stability and reduced interference with other molecules, making it a valuable component in the development of new chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, o-Aminophenol-d4 can be employed as a starting material or intermediate for the synthesis of various drug candidates. Its deuterated form may offer improved pharmacokinetic properties, such as enhanced solubility, bioavailability, or reduced metabolism, which can be beneficial in the development of more effective medications.
Used in Analytical Chemistry:
o-Aminophenol-d4 can also be utilized in analytical chemistry as a labeled internal standard or a reference compound for various analytical techniques, such as mass spectrometry or nuclear magnetic resonance (NMR) spectroscopy. Its deuterated nature allows for better differentiation and quantification of target molecules in complex samples.

Upstream product

• 93951-78-1 o-nitrophenol-d₄ 
• 95-55-6 2-amino-phenol 

Downstream Products

• 1021325-54-1 o-iodophenol-3,4,5,6-d4 
• 1146955-92-1 C₁₀H₇⁽²⁾H₄NO₃ 

Relevant academic research and scientific papers

2H-1,4-BENZOXAZIN-3(4H)-ONE, AN INTERMEDIATE IN THE BIOSYNTHESIS OF CYCLIC HYDROXAMIC ACIDS IN MAIZE

2H-1,4-Benzoxazin-3(4H)-one has been identified as an intermediate in the biosynthesis of cyclic hydroxamic acids in maize by showing that the deuterium labelled compound is incorporated into DIMBOA with high retention of deuterium and high efficiency, by trapping radioactivity from anthranilic acid in a pool of unlabelled benzoxazinone administered to maize shoots, and by showing that benzoxazinone is oxidized to DIBOA by maize microsomes in an NADPH- and oxygen-dependent reaction.

Synthesis of highly deuterium-labeled (R)-K-13675, PPAR α agonist, for use as an internal standard for low-level quantification of drugs in plasma

Two highly deuterium-labeled compounds, (R)-K-13675-d11 and (R)-K-13675-d7, were prepared for use as internal standards for low-level quantification of plasma drugs by LC/MS/MS. We successfully demonstrated their utility in pharmacok

Efficient and selective Pt/C-catalyzed H-D exchange reaction of aromatic rings

An effective and applicable deuteration method for aromatic rings using Pt/C-D2O-H2 system was established. Especially, phenol was fully deuterated even at room temperature, and other electron-rich aromatic nuclei were efficiently deuterated under mild conditions. The scope and limitations of the presence method and its application to the synthesis of deuterium-labeled biologically active compounds and deuterium-labeled building blocks for practical multi-gram scale syntheses are reported. 2008 The Chemical Society of Japan.

Aromatic ring favorable and efficient H-D exchange reaction catalyzed by Pt/C

An effective and applicable Pt/C-catalyzed deuteration method of aromatic rings using D2O as a deuterium source under hydrogen atmosphere was developed. Five percent Pt/C would lead to quite effective H-D exchange results on the aromatic ring systems. The reaction is general for a variety of aromatic compounds including biologically active compounds.