1218924-66-3Relevant academic research and scientific papers
Enantioselective addition of phenylacetylene to aldehydes catalyzed by polymer-supported titanium(IV) complexes of β-hydroxy amides
Hui, Xin-Ping,Huang, Lu-Ning,Li, Ya-Min,Wang, Ren-Lin,Xu, Peng-Fei
experimental part, p. 347 - 354 (2010/11/19)
A series of polymer-supported chiral β-hydroxy amides and C 2-symmetric β-hydroxy amides have been synthesized and successfully used for the enantioselective addition of phenylacetylene to aldehydes. High yields (up to 93%) and enantioselectivities (up to 92% ee) were achieved by using polymer-supported chiral bhydroxy amide 4b. The resin 4b is reused four times, giving the product with enantioselectivity 80% ee. Fortunately, it is found that this heterogonous system is suitable not only for aromatic aldehydes but also aliphatic aldehyde.
