1218996-42-9Relevant articles and documents
Piperazinyl pyrimidine derivatives as potent γ-secretase modulators
Rivkin, Alexey,Ahearn, Sean P.,Chichetti, Stephanie M.,Kim, Yoona R.,Li, Chaomin,Rosenau, Andrew,Kattar, Sam D.,Jung, Joon,Shah, Sanjiv,Hughes, Bethany L.,Crispino, Jamie L.,Middleton, Richard E.,Szewczak, Alexander A.,Munoz, Benito,Shearman, Mark S.
scheme or table, p. 1269 - 1271 (2010/06/15)
The development of a novel series of piperazinyl pyrimidines as γ-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein. Optimization of a screening hit provided a series of potent γ-secretase modulators with >