43212-41-5Relevant articles and documents
HEPATITIS B VIRAL ASSEMBLY EFFECTORS
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Paragraph 00162, (2016/10/31)
Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.
Development of an efficient, scalable route for the preparation of a novel insulin-like growth factor-1 receptor modulator
Kumar, C.H. Vinod,Kavitake, Santosh,Kumar, Sythana Suresh,Cornwall, Philip,Ashok, Mithun,Bhagat, Sagar,Manjunatha, Sulur G.,Nambiar, Sudhir
, p. 1416 - 1421 (2012/10/29)
A chromatography-free and efficient synthesis of insulin-like growth factor-1 receptor (IGF-1R) modulator is reported. Herein we describe an improved synthesis for the target compound, which features facile introduction of a novel pyrrolidinyl-pyrimidyl isoxazole 8, via in situ sulfone displacement by fluorine. The overall process consists of six chemical steps and five isolations, with introduction of the expensive triheterocyclic unit 8 towards the end of the synthesis.
AMINO-THIAZOLYL- PYRIMIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF CANCER
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Page/Page column 57-58, (2009/01/20)
The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These compounds provide a treatment for myeloproliferative disorders and cancer.