1219-42-7

Usage

Uses

Used in Chemical Research:
N'-[1-(2-Pyridinyl)ethylidene]benzohydrazide is used as a chemical compound in the field of chemical research for the study of its properties and potential applications. Its formation of a copper complex with a distorted octahedral geometry provides insights into the coordination chemistry and bonding characteristics of such complexes.
Used in Pharmaceutical Industry:
N'-[1-(2-Pyridinyl)ethylidene]benzohydrazide is used as a starting material or intermediate in the synthesis of pharmaceutical compounds. Its unique structure and ability to form complexes with metal ions, such as copper, may offer potential applications in the development of new drugs with novel therapeutic properties.
Used in Coordination Chemistry:
N'-[1-(2-Pyridinyl)ethylidene]benzohydrazide is used as a ligand in coordination chemistry for the formation of metal complexes. Its coordination with metal ions, such as copper, can lead to the development of new coordination compounds with potential applications in various fields, including catalysis, materials science, and supramolecular chemistry.

Upstream product

• 1122-62-9 2-acetylpyridine 
• 613-94-5 benzoic acid hydrazide 
• 93-89-0 benzoic acid ethyl ester 
• 93-58-3 benzoic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and characterization of transition metal complexes derived from (E)-N-(1-(Pyridine-2-yl)ethylidiene)benzohydrazide (PEBH)

Three metal complexes derived from (E)-N-(1-(pyridine-2-yl)ethylidene) benzohydrazide (PEBH) with Cu(II), Co(II), and Ni(II) have been synthesized and characterized using elemental analyses, spectral analyses (infrared [IR], ultraviolet [UV], mass spectroscopy [MS], nuclear magnetic resonance [ 1H-NMR]), thermal analyses, conductance, and magnetic measurements. The results showed that 1:1 (M:L) chelates with the general formula [M L Ac]nH2O have been formed. IR and 1H-NMR spectra of the ligand (E)-N-(1-(pyridine-2-yl)ethylidene)benzohydrazide (PEBH) showed that the free ligand exists in the keto form, while it binds to the metal ions in the enol form. The difference between as and s stretching vibrations of the acetate group suggests the monodentate nature of this group. Some semiempirical calculations of the vibrational spectra have been done using AM1, PM3, and ZINDO/1 methods to assist in the assignments of the experimental results. The optical band gap (Eg) values of Co, Ni, and Cu were found to be 3.4, 1.45, and 1.20 eV, respectively, arising from direct transitions. These values indicate the semiconductivity nature of these complexes. Copyright Taylor &Francis Group, LLC.

Mixed ligand complexes of nickel (II) dialkyldithiophosphates with 2-acetylpyridine semicarbazone and 2-acetylpyridine benzoylhydrazone

Dialkyldithiophosphates nickel (II) complexes react with Apsc and HApBH to yield mixed ligand complexes of the types [Ni{(RO)2PS2}2(Apsc)] and [Ni{(RO)2PS2}(ApBH)] where R = methyl, ethyl or propyl; A

Organometallic ruthenium(II) complexes: Synthesis, structure and influence of substitution at azomethine carbon towards DNA/BSA binding, radical scavenging and cytotoxicity

Bivalent, ruthenium organometallics containing hydrazone ligands with the composition [RuH(CO)(PPh3)2(L1-3)] (4-6) have been synthesised from the reactions of [RuH2(CO)(PPh 3)3] and benzoic

Synthesis, crystal structure, electrochemistry and studies on protein binding, antioxidant and biocidal activities of Ni(II) and Co(II) hydrazone complexes

Bivalent transition metal hydrazone complexes of the composition [Ni(L 1)2] (1), [Co(L1)2] (2), [Ni(L 2)2] (3) and [Co(L2)2] (4) have been synthesised from the reactio

Structural aspects and spectroscopic characterization of a Mn(II) complex with unsymmetrical NNO-donor hydrazone ligand

The manganese(II) complex, Mn[C5H4N-C(CH 3)=N-N=C(O)-C6H5]2 (1) containing N,N,O-donor hydrazone ligand is characterized by X-ray diffraction study. The ligand is the 1:1 condensation produ

Discovery of an Orally Efficacious MYC Inhibitor for Liver Cancer Using a GNMT-Based High-Throughput Screening System and Structure-Activity Relationship Analysis

Glycine-N-methyl transferase (GNMT) downregulation results in spontaneous hepatocellular carcinoma (HCC). Overexpression of GNMT inhibits the proliferation of liver cancer cell lines and prevents carcinogen-induced HCC, suggesting that GNMT induction is a potential approach for anti-HCC therapy. Herein, we used Huh7 GNMT promoter-driven screening to identify a GNMT inducer. Compound K78 was identified and validated for its induction of GNMT and inhibition of Huh7 cell growth. Subsequently, we employed structure-activity relationship analysis and found a potent GNMT inducer, K117. K117 inhibited Huh7 cell growth in vitro and xenograft in vivo. Oral administration of a dosage of K117 at 10 mpk (milligrams per kilogram) can inhibit Huh7 xenograft in a manner equivalent to the effect of sorafenib at a dosage of 25 mpk. A mechanistic study revealed that K117 is an MYC inhibitor. Ectopic expression of MYC using CMV promoter blocked K117-mediated MYC inhibition and GNMT induction. Overall, K117 is a potential lead compound for HCC- and MYC-dependent cancers.

Synthesis, molecular docking studies, anticancer and antibacterial activities of some novel dinuclear nickel (Ii) complexes 2, 4-dihydroxy acetyl-4-hydroxybenzoic hydrazone

Substituted 2, 4-Dihydroxyacetyl-4-Hydroxybenzoic Hydrazone, which is known for their versatile biological activities, have been reported to show significant anti lung cancer activities. In the present study, a novel series of some 2, 4-Dihydroxyacetyl-4-

Mononuclear and binuclear Cu(II) complexes of some tridentate aroyl hydrazones. X-ray crystal structures of a mononuclear and a binuclear complex

Cu(II) complexes of eight N,N,O-donor hydrazone ligands, obtained by condensation of pyridine-2-carbaldehyde and 2-acetylpyridine with four aroyl hydrazides, are reported. Reactions of Cu(ClO4)2· 6H2O with the pyridine-2-c

Coordination versatility of tridentate pyridyl aroylhydrazones towards iron: Tracking down the elusive aroylhydrazono-based ferric spin-crossover molecular materials

The two potentially tridentate and monoprotic Schiff bases acetylpyridine benzoylhydrazone (HL1) and acetylpyridine 4-tert- butylbenzoylhydrazone (HL2) demonstrate remarkable coordination versatility towards iron on account of their

Use of acylhydrazine- and acylhydrazone-type ligands to promote CuI-catalyzed C-N cross-coupling reactions of aryl bromides with N-heterocycles

A series of ten acylhydrazine- and acylhydrazone-type ligands were designed and synthesized. Their electronic and steric properties were easily modified and tuned by varying the substituents in the vicinity of the acylhydrazine and acylhydrazone units. The effect of ligands on the catalytic activity of Ullmann reactions was assessed by using a combination of these ligands with CuI. The catalytic system is very efficient for the C-N coupling reaction of azoles with aryl and heteroaryl bromides. A simple and efficient procedure for copper-catalyzed C-N cross-coupling reactions between aryl bromides and NH-containingheterocycles is illustrated. Readily available acylhydrazine- and acylhydrazone-typeligands promote the reaction.