1219-68-7

Basic information

• Product Name: 1,3-BIS-(2-CHLORO-PHENYL)-THIOUREA
• Synonyms: Carbanilide,2,2'-dichlorothio- (7CI,8CI); 1,3-Bis(o-chlorophenyl)thiourea;N,N'-Bis(2-chlorophenyl)thiourea; N,N'-Bis(o-chlorophenyl)thiourea; NSC 243607
• CAS NO: 1219-68-7
• Molecular Formula: C₁₃H₁₀Cl₂N₂S
• Molecular Weight: 0
• Mol File: 1219-68-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 392.7°C at 760 mmHg
• Flash Point: 191.3°C
• Appearance: /
• Density: 1.474g/cm³
• Vapor Pressure: 2.25E-06mmHg at 25°C
• Refractive Index: 1.749
• CAS DataBase Reference: 1,3-BIS-(2-CHLORO-PHENYL)-THIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-BIS-(2-CHLORO-PHENYL)-THIOUREA(1219-68-7)
• EPA Substance Registry System: 1,3-BIS-(2-CHLORO-PHENYL)-THIOUREA(1219-68-7)

Safety Data

• Hazardous Substances Data: 1219-68-7(Hazardous Substances Data)

Usage

General Description

1,3-Bis-(2-chloro-phenyl)-thiourea is a chemical compound with the molecular formula C13H10Cl2N2S. It is a thiourea derivative that is used as a raw material in the production of rubber accelerators and as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a white to off-white crystalline solid that is insoluble in water but soluble in organic solvents. 1,3-Bis-(2-chloro-phenyl)-thiourea is known for its potential applications in the field of organic synthesis and medicinal chemistry due to its unique structure and properties. However, it is important to handle this compound with care as it may pose health and environmental hazards if not used and disposed of properly.

InChI:InChI=1/C13H10Cl2N2S/c14-9-5-1-3-7-11(9)16-13(18)17-12-8-4-2-6-10(12)15/h1-8H,(H2,16,17,18)

Upstream product

• 56-23-5 tetrachloromethane 
• 95-51-2 o-chloroaniline 
• 7722-84-1 dihydrogen peroxide 
• 2740-81-0 2-chlorophenylisothiocyanate 
• 463-71-8 thiophosgene 
• 75-15-0 carbon disulfide 

Downstream Products

• 20440-52-2 3-(2-chloro-phenyl)-2-(2-chloro-phenylimino)-4-methyl-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester 
• 79051-57-3 2-(o-chlorophenylimino)-3-(o-chlorophenyl)-4,5-tetramethylene-Δ4-thiazoline 
• 82694-20-0 (2-Chloro-phenyl)-[3-(2-chloro-phenyl)-5-ethyl-4-methyl-3H-thiazol-(2Z)-ylidene]-amine 
• 92426-94-3 3-(2-chloro-phenyl)-2-(2-chloro-phenylimino)-thiazolidin-4-one 
• 82686-61-1 (2-Chloro-phenyl)-[3-(2-chloro-phenyl)-5-isopropyl-4-methyl-3H-thiazol-(2Z)-ylidene]-amine 
• 79051-15-3 2-(o-chlorophenylimino)-3-(o-chlorophenyl)-4-(p-tolyl)-Δ4-thiazoline 
• 79051-30-2 2-(o-chlorophenylimino)-3-(o-chlorophenyl)-4-(p-ethoxyphenyl)-Δ4-thiazoline 
• 82694-53-9 (2-Chloro-phenyl)-[3-(2-chloro-phenyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amine 
• 92426-94-3 3-(2-chlorophenyl)-2-(2-chlorophenylimino)thiazolidin-4-one 
• 1352834-03-7 {4-[3-(2-chlorophenyl)-2-(2-chlorophenylimino)-4-oxothiazolidin-5-ylidenemethyl]phenoxy}acetic acid 
• 1308272-81-2 (2-chlorophenyl)-[1-(2-chlorophenyl)-1H-tetrazol-5-yl]-amine 
• 13208-19-0 N,N'-bis(2-chlorophenyl)urea 
• 79051-45-9 2-(o-chlorophenylimino)-3-(o-chlorophenyl)-4-(m-nitrophenyl)-Δ4-thiazoline 
• 82694-36-8 (2-Chloro-phenyl)-[3-(2-chloro-phenyl)-4-ethyl-5-methyl-3H-thiazol-(2Z)-ylidene]-amine 

Relevant articles and documents

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections

Targeting secreted aspartic protease 2 (SAP2), a kind of virulence factor, represents a new strategy for antifungal drug discovery. In this report, the first-generation of small molecule SAP2 inhibitors was rationally designed and optimized using a structure-based approach. In particular, inhibitor 23h was highly potent and selective and showed good antifungal potency for the treatment of resistant Candida albicans infections.

Synthesis of thioureas in ionic liquid medium

A highly efficient procedure for the synthesis of symmetrical thioureas by means of simple condensation of primary amines and carbon disulfide in 1-butyl-3-methylimidazolium chloride [BMIM][Cl] as a cheap and commercially available ionic liquid is presented. This procedure works for aromatic and aliphatic primary amines and give high to excellent yields of symmetrical thioureas without need for any catalyst or tedious work-up.

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A series of halogenated 2-arylimino-3-ary-thiazolidine-4-ones containing (5-furan-2-yl)-benzoic acid or (5-thiophene-2-yl)-benzoic acid fragments was synthesized, and evaluated in vitro for their antibacterial activity, antibiofilm activity, erythrocyte h