1219-68-7

Usage

Uses

Used in Rubber Industry:
1,3-Bis-(2-chloro-phenyl)-thiourea is used as a raw material in the production of rubber accelerators, which are essential for enhancing the vulcanization process and improving the physical properties of rubber products.
Used in Pharmaceutical Industry:
1,3-Bis-(2-chloro-phenyl)-thiourea serves as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
1,3-BIS-(2-CHLORO-PHENYL)-THIOUREA is also utilized as an intermediate in the synthesis of agrochemicals, playing a role in the production of pesticides and other agricultural chemicals to protect crops and enhance yield.
It is crucial to handle 1,3-Bis-(2-chloro-phenyl)-thiourea with care, as it may pose health and environmental hazards if not used and disposed of properly.

InChI:InChI=1/C13H10Cl2N2S/c14-9-5-1-3-7-11(9)16-13(18)17-12-8-4-2-6-10(12)15/h1-8H,(H2,16,17,18)

Upstream product

• 95-51-2 o-chloroaniline 
• 7722-84-1 dihydrogen peroxide 
• 56-23-5 tetrachloromethane 
• 2740-81-0 2-chlorophenylisothiocyanate 
• 463-71-8 thiophosgene 
• 75-15-0 carbon disulfide 

Downstream Products

• 92426-94-3 3-(2-chloro-phenyl)-2-(2-chloro-phenylimino)-thiazolidin-4-one 
• 20440-52-2 3-(2-chloro-phenyl)-2-(2-chloro-phenylimino)-4-methyl-2,3-dihydro-thiazole-5-carboxylic acid ethyl ester 
• 36220-34-5 (2-chloro-phenyl)-[3-(2-chloro-phenyl)-4-phenyl-3H-thiazol-2-ylidene]-amine 
• 82844-59-5 1,3-Bis-(2-chloro-phenyl)-5,5-bis-(4-hydroxy-phenyl)-2-thioxo-imidazolidin-4-one 
• 79051-45-9 2-(o-chlorophenylimino)-3-(o-chlorophenyl)-4-(m-nitrophenyl)-Δ4-thiazoline 
• 1308272-81-2 (2-chlorophenyl)-[1-(2-chlorophenyl)-1H-tetrazol-5-yl]-amine 
• 92426-94-3 3-(2-chlorophenyl)-2-(2-chlorophenylimino)thiazolidin-4-one 
• 13208-19-0 N,N'-bis(2-chlorophenyl)urea 
• 82694-53-9 (2-Chloro-phenyl)-[3-(2-chloro-phenyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amine 
• 79051-30-2 2-(o-chlorophenylimino)-3-(o-chlorophenyl)-4-(p-ethoxyphenyl)-Δ4-thiazoline 
• 82694-36-8 (2-Chloro-phenyl)-[3-(2-chloro-phenyl)-4-ethyl-5-methyl-3H-thiazol-(2Z)-ylidene]-amine 
• 79051-15-3 2-(o-chlorophenylimino)-3-(o-chlorophenyl)-4-(p-tolyl)-Δ4-thiazoline 
• 130749-42-7 6-amino-1,3-di(2-chlorobenzene)-2-thiouracil 
• 82686-61-1 (2-Chloro-phenyl)-[3-(2-chloro-phenyl)-5-isopropyl-4-methyl-3H-thiazol-(2Z)-ylidene]-amine 

Relevant academic research and scientific papers

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections

Targeting secreted aspartic protease 2 (SAP2), a kind of virulence factor, represents a new strategy for antifungal drug discovery. In this report, the first-generation of small molecule SAP2 inhibitors was rationally designed and optimized using a structure-based approach. In particular, inhibitor 23h was highly potent and selective and showed good antifungal potency for the treatment of resistant Candida albicans infections.

A simple and straightforward synthesis of phenyl isothiocyanates, symmetrical and unsymmetrical thioureas under ball milling

Promoted by KOH under ball milling, anilines were efficiently transformed into isothiocyanates (in presence of 5.0 equiv. CS2) or symmetrical thioureas (in presence of 1.0 equiv. CS2), without using any other harsh or toxic decomposition reagent. Some in situ generated isothiocyanates can directly "click" with other amines to afford unsymmetrical thioureas.

Synthesis of thioureas in ionic liquid medium

A highly efficient procedure for the synthesis of symmetrical thioureas by means of simple condensation of primary amines and carbon disulfide in 1-butyl-3-methylimidazolium chloride [BMIM][Cl] as a cheap and commercially available ionic liquid is presented. This procedure works for aromatic and aliphatic primary amines and give high to excellent yields of symmetrical thioureas without need for any catalyst or tedious work-up.

Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis

A series of novel substituted 4-thiazolidione derivatives were designed, synthesized, and evaluated in vitro for their antibacterial activities, in comparison with methicillin and ampicillin. Compounds (7d, 7h-k) exhibit good potency in inhibiting the growth of Staphylococcus epidermidis (MIC: 1.57-3.13 μM). Further antibacterial effects of compounds (7d, 7h-k) were investigated using clinical isolates (methicillin-resistant Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus), in comparison with methicillin and levofloxacin. Compound 7k showed the most potent antibacterial activities among the synthesized compounds.

Synthesis and biological evaluation of halogenated 2-arylimino-3- arythiazolidine-4-ones containing benzoic acid fragments as antibacterial agents

A series of halogenated 2-arylimino-3-ary-thiazolidine-4-ones containing (5-furan-2-yl)-benzoic acid or (5-thiophene-2-yl)-benzoic acid fragments was synthesized, and evaluated in vitro for their antibacterial activity, antibiofilm activity, erythrocyte h

Tandem regioselective synthesis of tetrazoles and related heterocycles using iodine

A one-pot, tandem process has been developed for the synthesis of a library of tetrazoles from aryl isothiocyanates. Condensation of aryl isothiocyanates with ammonia, and aryl amines (R-NH2) provided mono, 1,3-disubstituted symmetrical and unsymmetrical thioureas, which on desulfurization with molecular iodine (I2) led to formation of the corresponding heterocumulene (cyanamides or carbodiimides). The in situ generated heterocumulene on subsequent treatment with sodium azide at room temperature gave corresponding tetrazoles. The product regioselectivity for unsymmetrical 1,3-disubstituted thioureas was found to be correlated with the basicities (pKa's) of the parent amines attached to the thiourea. Aryl-sec-alkyl unsymmetrical thioureas gave thioamido guanidino products rather than the 5-aminotetrazoles produced by HgCl2 mediation of the reaction. Bis-thioureas derived from aryl isothiocyanates and hydrazine gave thiadiazoles exclusively.

Carbon tetrabromide promoted reaction of amines with carbon disulfide: Facile and efficient synthesis of thioureas and thiuram disulfides

A novel carbon tetrabromide promoted one-pot reaction of amines and carbon disulfide under mild conditions has been developed, which provides a straightforward and efficient access to thioureas and thiuram disufides, depending on the nature of the amines employed. The promotion effect is explained as the transient formation of a sulfenyl bromide intermediate from dithiocarbamate and carbon tetrabromide during the reaction. Georg Thieme Verlag Stuttgart · New York.

A Concise and Convenient Method for the Synthesis of Pure Substituted Thioureas

Zinc dialkyldithiocarbamates offer excellent substrates for pure thioureas required for the ntifungal and X-ray crystallographic studies.

Lac sulfur assisted synthesis of symmetrical thioureas

This work presents a short and attractive method to synthesise a variety of 1,3-disubstituted symmetrical thioureas in high yields.

Applications of Phase Transfer Catalysis, 26. - Thioureas by Three-Component Reactions of Amines, Carbon Tetrachloride, and Sulfide Ions

The title reactions proceed exothermically in the presence of a phase transfer catalyst.Thiophosgene is an intermediate in this conversion, and its phase transfer catalytic transformation into carbon disulfide and trithiocarbonate can be demonstrated.Perchloromethanethiol/sodium sulfide and a PT catalyst yield thiophosgene too.Activated vicinal dibromides were debrominated by Na2S/catalyst.