1219015-58-3Relevant academic research and scientific papers
Bicyclic peptides as potent inhibitors of histone deacetylases: Optimization of alkyl loop length
Islam, Nurul M.,Kato, Tamaki,Nishino, Norikazu,Kim, Hyun-Jung,Ito, Akihiro,Yoshida, Minoru
, p. 997 - 999 (2010)
Bicyclic tetrapeptide hydroxamic acids were prepared as histone deacetylase (HDAC) inhibitors, and the evaluated inhibitory activity shows that they are potent against HDAC1 and HDAC4. The in vivo activity depends on alkyl loop length.
