1219362-86-3Relevant academic research and scientific papers
Parallel solution phase synthesis of 3,6,7-4(3 H)-Quinazolinones and evaluation of their antitumor activities against human cancer
Wu, Hao,Xie, Xilei,Liu, Gang
experimental part, p. 346 - 355 (2010/10/18)
Three diversity points of 4(3H)-quinazolinone are introduced at the 3-, 6-, and 7-positions with an efficient parallel solution-phase synthetic method. A one-pot synthesis was developed that gave the key intermediate in high yield. Five hit compounds exhibit preferable activities against a panel of human tumor cell lines, which pointed out preliminary structure-activity relationships.
