1219617-91-0

Upstream product

• 1369593-18-9 C₁₂H₁₃BrO 
• 1122-91-4 4-bromo-benzaldehyde 
• 627-19-0 1-Pentyne 
• 1072835-11-0 C₁₂H₁₁BrO 
• 69555-14-2 ethyl N-diphenylmethylene glycine 

Downstream Products

• 1262229-75-3 C₁₄H₁₄BrNO₂ 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 3-amino-2-pyrones as selective cyclooxygenase-1 (COX-1) inhibitors

A group of 3-amino-2-pyrones were synthesized and their biological activities were evaluated for inhibiting cyclooxygenase (COX) activity. This study has led to the identification of COX-1-selective inhibitors. Among the tested compounds, the compound 5j exhibited the most potent COX-1 inhibitory activity (IC50 = 19.32 μg/mL) and COX-1 selectivity index (SI = 41.98).

Michael addition-lactonization reaction of electron-deficient alkynes with n-(Diphenylmethylene)glycinates: An efficient synthesis of 3-Amino-2-pyrone Derivatives

A mild and efficient process for the synthesis of 3-amino-2-pyrone derivatives has been developed. This approach is based on the Michael addition of N-(diphenylmethylene)glycinates to various alkynyl ketones, followed by lactonization using 10 mol% sodium hydroxide as catalyst. Aromatic and aliphatic alkynyl ketones were converted into the corresponding 3-amino-2-pyrone derivatives in moderate to high yields. When methyl propiolate was submitted to the reaction,α,β-dehydroamino acids were formed in good yields. Georg Thieme Verlag Stuttgart.