1369593-18-9Relevant academic research and scientific papers
Synthesis and biological evaluation of 3-amino-2-pyrones as selective cyclooxygenase-1 (COX-1) inhibitors
Chu, Xue-Ping,Zhou, Qing-Fa,Zhao, Shen,Ge, Fei-Fei,Fu, Mian,Chen, Jia-Peng,Lu, Tao
, p. 120 - 122 (2013)
A group of 3-amino-2-pyrones were synthesized and their biological activities were evaluated for inhibiting cyclooxygenase (COX) activity. This study has led to the identification of COX-1-selective inhibitors. Among the tested compounds, the compound 5j exhibited the most potent COX-1 inhibitory activity (IC50 = 19.32 μg/mL) and COX-1 selectivity index (SI = 41.98).
