1219623-41-2

Upstream product

• 3469-00-9 methyl 2,2-diphenylacetate 
• 6309-36-0 3,3-diphenyl-2-pyrrolidone 
• 105-36-2 ethyl bromoacetate 
• 956-89-8 3,3-Diphenyl-dihydro-furan-2-one 

Downstream Products

• 1219623-42-3 2-(2-oxo-3,3-diphenylpyrrolidin-1-yl)acetic acid 
• 1219623-40-1 1-[2-(4-benzhydrylpiperazin-1-yl)-2-oxoethyl]-3,3-diphenylpyrrolidin-2-one 
• 1219624-19-7 1-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}-2-oxoethyl)-3,3-diphenylpyrrolidin-2-one 
• 1219624-18-6 1-(2-{4-[(4-fluorophenyl)(phenyl)methyl]piperazin-1-yl}-2-oxoethyl)-3,3-diphenylpyrrolidin-2-one 
• 1219624-17-5 1-(2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-oxoethyl)-3,3-diphenylpyrrolidin-2-one 
• 1219623-88-7 1-{2-[4-(4-fluorobenzyl)piperazin-1-yl]-2-oxoethyl}-3,3-diphenylpyrrolidin-2-one 
• 1219623-87-6 1-(2-oxo-2-{4-[3-(trifluoromethyl)benzyl]piperazin-1-yl}ethyl)-3,3-diphenylpyrrolidin-2-one 
• 1219624-09-5 1-{2-[4-(2,4-dichlorobenzyl)piperazin-1-yl]-2-oxoethyl}-3,3-diphenylpyrrolidin-2-one 
• 1219623-86-5 1-{2-[4-(2,6-dichlorobenzyl)piperazin-1-yl]-2-oxoethyl}-3,3-diphenylpyrrolidin-2-one 
• 1334536-82-1 1-(2-oxo-2-piperazin-1-ylethyl)-3,3-diphenylpyrrolidin-2-one 
• 1334536-93-4 Benzyl 4-(2-(2-oxo-3,3-diphenylpyrrolidin-1-yl)acetyl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

Discovery of diphenyl lactam derivatives as N-type calcium channel blockers

A novel series of diphenyl lactam containing calcium channel blockers is described. Extensive SAR studies resulted in compounds with low molar activity and good plasma exposure after oral dosing. Compounds 2, 6 and 7 demonstrated significant efficacy in the capsaicin model of secondary hyperalgesia following oral administration.

LACTAM ACETAMIDES AS CALCIUM CHANNEL BLOCKERS

The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, n, R1, X and Y are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

NOVEL COMPOUNDS AS CALCIUM CHANNEL BLOCKERS

The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, Ar2, L1, L2, n, R1, R4, X and Y are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.