121983-85-5Relevant academic research and scientific papers
THE BIOSYNTHESIS OF SCELETIUM ALKALOIDS IN SCELETIUM SUBVELUTINUM L. BOLUS
Herbert, Richard B.,Kattah, Abdullah E.
, p. 7105 - 7118 (2007/10/02)
Six Sceletium (Mesembrine) alkaloids (1)-(6) are identified, together with N,N-dimethyltyramine (10), as constituents of Sceletium subvelutinum.The alkaloids (1)-(6) incroporate label from tyramine and 3-(-4-hydroxyphenyl)propionic acid (13) as expected; notably 3-(-4-hydroxyphenyl)propanal (15) is a more efficient alkaloid precursor than is the acid (13) and the aldehyde is deduced to be a key intermediate in the biosynthesis of Sceletium alkaloids.The N-methylamine (21) is an important late intermediate in the biosynthesis of Sceletium alkaloids, or is closely related to that intermediate.The amine (2) is less efficiently incorporated than (22)=(21) is.
