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1219948-76-1

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1219948-76-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1219948-76-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,9,9,4 and 8 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1219948-76:
(9*1)+(8*2)+(7*1)+(6*9)+(5*9)+(4*4)+(3*8)+(2*7)+(1*6)=191
191 % 10 = 1
So 1219948-76-1 is a valid CAS Registry Number.

1219948-76-1Upstream product

1219948-76-1Downstream Products

1219948-76-1Relevant articles and documents

Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532

Ushiyama, Fumihito,Takashima, Hajime,Matsuda, Yohei,Ogata, Yuya,Sasamoto, Naoki,Kurimoto-Tsuruta, Risa,Ueki, Kaori,Tanaka-Yamamoto, Nozomi,Endo, Mayumi,Mima, Masashi,Fujita, Kiyoko,Takata, Iichiro,Tsuji, Satoshi,Yamashita, Haruhiro,Okumura, Hirotoshi,Otake, Katsumasa,Sugiyama, Hiroyuki

, (2021)

Infectious diseases caused by resistant Gram-negative bacteria have become a serious problem, and the development of therapeutic drugs with a novel mechanism of action and that do not exhibit cross-resistance with existing drugs has been earnestly desired. UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is a drug target that has been studied for a long time. However, no LpxC inhibitors are available on the market at present. In this study, we sought to create a new antibacterial agent without a hydroxamate moiety, which is a common component of the major LpxC inhibitors that have been reported to date and that may cause toxicity. As a result, a development candidate, TP0586532, was created that is effective against carbapenem-resistant Klebsiella pneumoniae and does not pose a cardiovascular risk.

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