121996-73-4Relevant academic research and scientific papers
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 3-OXO-3H-PYRIDOPHENOXAZINE-2-CARBOXYLIC ACIDS
Radl, Stanislav,Zikan, Viktor
, p. 506 - 515 (2007/10/02)
Reaction of ethyl 1,4-dihydro-8-hydroxy-4-oxo-3-quinolinecarboxylates XIIIa - XIIIc with 2,4-dinitrochlorobenzene in N,N-dimethylformamide in the presence of sodium hydrogen carbonate yields appropriate ethyl 3-oxo-3H-pyridophenoxazine-2-carboxylates XIVa - XIVc.Similar reaction of XIIIa and XIIIb in aqueous solution yields mixtures of the respective ester (XIVa and XIVb, respectively) and acid (XIVd and XIVe, respectively).Compounds XIVg - XIVj were prepared by usual methods.The compounds prepared were tested for their antimicrobial activity in vitro.
