1219981-82-4

Upstream product

• 1219981-74-4 C₁₂H₁₉IO₅ 
• 1219981-70-0 (S)-pent-4-en-2-yl benzoate 
• 65756-08-3 (S)-(+)-6-Heptyn-2-ol 
• 26059-43-8 hept-3-yn-2-one 
• 627-19-0 1-Pentyne 
• 1361250-53-4 (2S,8R,11S,Z)-7-benzyldimethylsilyl-8-(tert-butyldimethylsilyloxy)-14-methoxy-11-methoxymethoxy-14-oxotetradec-6-en-12-yn-2-yl benzoate 
• 1361250-51-2 (2S,8R,Z)-7-(benzyldimethylsilyl)-8-((tert-butyldimethylsilyl)oxy)-11-oxoundec-6-en-2-yl benzoate 
• 1361250-50-1 (2S,8R,Z)-7-benzyldimethylsilyl-8-(tert-butyldimethylsilyloxy)-11,11-dimethoxyundec-6-en-2-yl benzoate 
• 1361250-59-0 (2S,8R,Z)-7-benzyldimethylsilyl-8-hydroxy-11,11-dimethoxyundec-6-en-2-yl benzoate 
• 1361250-49-8 (2S,6Z,8R,9E)-7-(benzyldimethylsilyl)-8-hydroxy-11,11-dimethoxyundeca-6,9-dien-2-yl benzoate 
• 1361250-58-9 (2S,8R,E)-8-hydroxy-11,11-dimethoxyundec-9-en-6-yn-2-yl benzoate 
• 1361250-47-6 (S)-hept-6-yn-2-yl benzoate 

Relevant academic research and scientific papers

Transition-metal-catalyzed synthesis of aspergillide B: An alkyne addition strategy

A catalytic enantioselective formal total synthesis of aspergillide B is reported. This linchpin synthesis was enabled by the development of new conditions for Zn-ProPhenol catalyzed asymmetric alkyne addition. This reaction was used in conjunction with ruthenium-catalyzed trans-hydrosilylation to affect the rapid construction of a late-stage synthetic intermediate of aspergillide B to complete a formal synthesis of aspergillide B in a highly efficient manner.

An enantioselective total synthesis of aspergillides A and B

An enantioselective total synthesis of aspergillides A and B has been accomplished on the basis of a unified synthetic strategy that exploits stereodivergent intramolecular oxa-conjugate cyclization and Yamaguchi macrolactonization.

A unified total synthesis of aspergillides A and B

An enantioselective total synthesis of aspergillides A and B has been accomplished based on a unified strategy, wherein a hydroxy-directed, highly chemoselective olefin cross-metathesis and a diastereoselective intramolecular oxa-conjugate cyclization were employed to forge the 2,6-substituted tetrahydropyran substructure.