1220-08-2

Upstream product

• 1633-22-3 [2.2]Paracyclophan 
• 6337-67-3 4,4'-bis(bromomethyl)bibenzyl 
• 31351-24-3 1-Tosyloxy<2.2>paracyclophan 
• 51359-78-5 4-(bromomethyl)benzaldehyde 
• 1122-91-4 4-bromo-benzaldehyde 
• 589-17-3 p-bromobenzyl chloride 
• 873-75-6 4-bromobenzenemethanol 
• 31351-27-6 1,2-Dibrom<2.2>paracyclophan 
• 31297-12-8 <2.2>paracyclophanene 
• 71776-83-5 4,4'-bis-acetoxymethyl-bibenzyl 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 33731-84-9 2,3-bis-(4-bromophenyl)propionic acid 
• 4381-02-6 1,2-bis-(4-cyanophenyl)ethane 
• 201230-82-2 carbon monoxide 

Downstream Products

• 3782-82-9 1,2-Bis-<4-(4-ethoxycarbonyl-phenyliminomethyl)-phenyl>-ethan 
• 3787-64-2 1.2-Bis-<4-(3-hydroxy-4-methoxycarbonyl-phenyliminomethyl)-phenyl>-aethan 
• 38058-86-5 1,2-bis<4-(chloromethyl)phenyl>ethane 
• 1205553-48-5 C₇₂H₇₄O₆ 
• 88579-95-7 C₅₂H₄₆P₂⁽²⁺⁾*2Br^(1-) 
• 6337-67-3 4,4'-bis(bromomethyl)bibenzyl 
• 629670-37-7 C₄₈H₅₀O₂S₄ 
• 629670-34-4 (4-{4-butyl-5-[4-(2-{4-[3-butyl-5-(4-hydroxymethyl-phenyl)-furan-2-yl]-phenyl}-ethyl)-phenyl]-furan-2-yl}-phenyl)-methanol 
• 629670-35-5 C₄₄H₄₄Br₂O₂ 
• 629670-36-6 C₄₄H₄₂O₄ 
• 629670-33-3 C₄₆H₄₆O₆ 
• 3782-74-9 1,2-Bis-<4-(4-carboxy-phenyliminomethyl)-phenyl>-ethan 
• 3525-56-2 1,2-Bis-<4-(4-methoxy-phenyliminomethyl)-phenyl>-aethan 
• 3525-67-5 1,2-Bis-(4-cyclohexyliminomethyl-phenyl)-aethan 

Relevant academic research and scientific papers

Controlling chain conformation in conjugated polymers using defect inclusion strategies

The Horner method was used to synthesize random copolymers of poly(2-methoxy-5-(2′-ethylhexyloxy)-p-phenylene vinylene) (MEH-PPV) that incorporated different backbone-directing monomers. Single-molecule polarization absorption studies of these new polymer

(4,4')TRANS-STILBENOPHANE

The title compound has been synthesised by a reductive coupling of bibenzyl-4,4'-dicarbaldehyde and its dynamic properties and photoinduced isomerisations are briefly described.

EPIDITHIODIKETOPIPERAZINE COMPOUNDS, COMPOSITIONS, AND METHODS

Epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of their synthesis, as part of treating, inhibiting and reducing transcription and translation of hypoxia inducible genes are described. In another aspect, the present disclosure describes a method for interfering with hypoxia-induced transcriptional pathway in a cell comprising: contacting the cell with at least one compound disclosed herein. In another aspect, the present disclosure describes a method for treating breast cancer, a solid cancer, a blood cancer, a subject suffering from carcinoma in need of said treatment, and renal cell carcinoma (RCC), comprising: administering to the subject an effective amount of at least one compound disclosed herein. In some embodiments of the methods described herein, the method further comprises administering an additional anti-cancer and/or cytotoxic agent.

Csp3-Csp3 homocoupling reaction of benzyl halides catalyzed by rhodium

A highly reactive alkylrhodium complex was formed from Me2Zn and RhCl(PPh3)3 and effectively catalyzed a Csp 3-Csp3 homocoupling reaction of benzyl halides. A Csp 3-Csp3 coupling reaction using Rh catalyst has not been reported up to now. The reaction proceeded under very mild conditions and gave the corresponding homocoupling products even if they had reactive substituents such as an uncovered formyl or hydroxymethyl group.

METHOD FOR PRODUCING 4,4'-DIFORMYLDIPHENYLALKANE

A method for producing a 4,4'-diformyldiphenylalkane represented by the following formula (2), containing formylating a diphenylalkane represented by the following formula (1) with carbon monoxide in the presence of hydrogen fluoride and boron trifluoride, in which the reaction temperature of the formylation is from -50 to 5°C, from 5 to 30 mol of hydrogen fluoride is used per 1 mol of the diphenylalkane, and from 1.5 to 5 mol of boron trifluoride is used per 1 mol of the diphenylalkane: wherein R represents an alkanediyl group having from 1 to 6 carbon atoms, wherein R represents an alkanediyl group having from 1 to 6 carbon atoms.

Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents

A new class of novel bis-benzimidazole diamidine compounds have been synthesized and evaluated for in vitro antibacterial activities, including drug-resistant bacterial strains. Anti-MRSA and anti-VRE activities of the most potent compound 1 were more act

Efficient light harvesting by sequential energy transfer across aggregates in polymers of finite conjugational segments with short aliphatic linkages

Interactions between lumophores have a critical influence on the photophysical properties of conjugated polymers. We synthesized a new series of light-harvesting polymers (poly-DSBs, I-IV) of dialkyloxy- or dialkyl- substituted distyrylbenzene (the substituents being methoxy, 2-ethylhexyloxy, and cyclohexyl) with short aliphatic linkage (methylene or ethylene) and examined the effects of interactions between lumophores and of chemical structures on the absorption, emission, and excitation spectra. The proximity between distyrylbenzene lumophores was shown to be critical to the interactions between lumophores and to the energy-transfer processes. In concentrated solutions and solid films, intermolecular aggregates exist resulting from different extents of interactions between lumophores and are found to involve at least three species: loose, compact, and the most aligned aggregates as observed by photoluminescence and excitation spectroscopies. We also found, for the first time, sequential energy transfer from individual lumophores to the most compact, aligned aggregates via the looser intermolecular aggregates, as observed directly by time-resolved fluorescence spectroscopy. Such a process mimics energy transfer in photosynthesis units and is so efficient such that the fluorescence color can be red-shifted drastically by the presence of comparatively few aggregates and that the light evolved from concentrated solutions and films of poly-DSBs I-IV is entirely or almost the aggregation emission. Although the sequential energy-transfer process in fully conjugated electro-/photoluminescent polymers due to inhomogenity other than distributed conjugation lengths has never been directly observed at room temperature, we suggest that events similar to those observed in poly-DSBs in conjugated polymers could occur but on a much shorter time scale, i.e., a few picoseconds.

Cyclophanes, XLVI oxidative carbon - carbon bond cleavage of a [2.2]paracyclophane derivative - efficient intramolecular trapping of the radical cation

4-(2,3,4,5-Tetraphenyl)phenyl[2.2]paracyclophane (3) has been prepared by cycloaddition of tetracyclone (2) to 4-ethynyl[2.2]paracyclophane (1). On treatment with FeCl3 or AlCl3 or NOBF4 in nitromethane, 3 undergoes C-C bond cleavage by an electron transfer process to provide the double benzyl radical cation 10. The phenyl groups of the aryl substituent are ideally oriented for intramolecular trapping and, in the presence of the Lewis acids, ring closure to the new phane system 5 takes place in good yield (65%). In the presence of NOBF4, the half-cyclized aldehyde 6 (66%) is produced. For comparison, [2.2]paracyclophane (7) was also treated with the latter one-electron oxidant, providing bibenzyl-4,4'-dicarbaldehyde (8, 30%) and its monooxime 9 (35%). The structures of the new phane systems 3 and 5 have been determined by X-ray structural analysis, and the mechanisms leading to these products are discussed.

Influence of Conformation and Proton-Transfer Dynamics in the Dibenzyl σ-Complex on Regioselectivity in Gattermann-Koch Formylation via Intracomplex Reaction

The Gattermann-Koch formylations of diphenyl, diphenylmethane, dibenzyl, and 1,3-diphenyl- propane were studied in HF-SbF5, -TaF5, -BF3, -NbF5, and CF3SO3H-SbF5. While usual high para regioselectivity was obtained for diphenyl, diphenylmethane, and 1,3-diphenylpropane, unprecedented ortho regioselectivity was observed for dibenzyl which increased with decreasing the SbF5/dibenzyl molar ratio and with strength of Lewis acids used in HF. A sandwich-like complex for monoprotonated dibenzyl resulting in ortho regioselectivity via the intracomplex reaction was suggested; therefore, the conformations of protonated diphenylmethane, dibenzyl, and 1,3- diphenylpropane and their proton-transfer dynamics were probed by semiempirical calculation (PM3). The calculation predicted that ortho monoprotonation was slightly preferable for dibenzyl, and remarkable preference of dibenzyl over other aromatic compounds was observed in ortho- ortho intramolecular inter-ring proton transfer via a fan-shaped complex rather than a sandwich- like complex. The experimental and theoretical data for dibenzyl are compatible with the intracomplex reaction, whereby CO is protonated by the ortho σ-complex undergoing rapid inter- ring proton transfer to generate formyl cation in the vicinity of the ortho position leading to ortho regioselectivity.

Structure-in vitro activity relationships of pentamidine analogues and dication-substituted bis-benzimidazoles as new antifungal agents

Twenty analogues of pentamidine, 7 primary metabolites of pentamidine, and 30 dicationic substituted bisbenzimidazoles were screened for their inhibitory and fungicidal activities against Candida albicans and Cryptococcus neoformans. A majority of the com